The peroxisome: an update on mysteries 3.0.

Membrane contact sites Motility Organelle biogenesis Organelle division Organelle dynamics Peroxin Peroxisome Protein import STED microscopy

Journal

Histochemistry and cell biology
ISSN: 1432-119X
Titre abrégé: Histochem Cell Biol
Pays: Germany
ID NLM: 9506663

Informations de publication

Date de publication:
20 Jan 2024
Historique:
accepted: 09 12 2023
medline: 20 1 2024
pubmed: 20 1 2024
entrez: 20 1 2024
Statut: aheadofprint

Résumé

Peroxisomes are highly dynamic, oxidative organelles with key metabolic functions in cellular lipid metabolism, such as the β-oxidation of fatty acids and the synthesis of myelin sheath lipids, as well as the regulation of cellular redox balance. Loss of peroxisomal functions causes severe metabolic disorders in humans. Furthermore, peroxisomes also fulfil protective roles in pathogen and viral defence and immunity, highlighting their wider significance in human health and disease. This has sparked increasing interest in peroxisome biology and their physiological functions. This review presents an update and a continuation of three previous review articles addressing the unsolved mysteries of this remarkable organelle. We continue to highlight recent discoveries, advancements, and trends in peroxisome research, and address novel findings on the metabolic functions of peroxisomes, their biogenesis, protein import, membrane dynamics and division, as well as on peroxisome-organelle membrane contact sites and organelle cooperation. Furthermore, recent insights into peroxisome organisation through super-resolution microscopy are discussed. Finally, we address new roles for peroxisomes in immune and defence mechanisms and in human disorders, and for peroxisomal functions in different cell/tissue types, in particular their contribution to organ-specific pathologies.

Identifiants

pubmed: 38244103
doi: 10.1007/s00418-023-02259-5
pii: 10.1007/s00418-023-02259-5
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/W015420/1, BB/V018167/1, BB/T002255/1, BB/R016844/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/W015420/1, BB/V018167/1, BB/T002255/1, BB/R016844/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/W015420/1, BB/V018167/1, BB/T002255/1, BB/R016844/1
Pays : United Kingdom

Informations de copyright

© 2024. The Author(s).

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Auteurs

Rechal Kumar (R)

Faculty of Health and Life Sciences, Department of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, EX4 4QD, UK.

Markus Islinger (M)

Institute of Neuroanatomy, Medical Faculty Mannheim, Mannheim Centre for Translational Neuroscience, University of Heidelberg, 68167, Mannheim, Germany.

Harley Worthy (H)

Faculty of Health and Life Sciences, Department of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, EX4 4QD, UK.

Ruth Carmichael (R)

Faculty of Health and Life Sciences, Department of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, EX4 4QD, UK. r.carmichael@exeter.ac.uk.

Michael Schrader (M)

Faculty of Health and Life Sciences, Department of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, EX4 4QD, UK. m.schrader@exeter.ac.uk.

Classifications MeSH