Layer-specific fast strain-encoded cardiac magnetic resonance imaging aids in the identification and discrimination of acute myocardial injury: a prospective proof-of-concept study.
CMR
Cardiovascular Imaging
Myocarditis
NSTEMI
Strain
fSENC
Journal
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
ISSN: 1532-429X
Titre abrégé: J Cardiovasc Magn Reson
Pays: England
ID NLM: 9815616
Informations de publication
Date de publication:
18 Jan 2024
18 Jan 2024
Historique:
received:
22
11
2023
accepted:
11
01
2024
medline:
21
1
2024
pubmed:
21
1
2024
entrez:
20
1
2024
Statut:
aheadofprint
Résumé
Acute myocardial injury is a common diagnosis in the emergency department and differential diagnoses are numerous. Cardiac magnetic resonance (CMR) strain sequences like fSENC are early predictors of myocardial function loss. This study assessed the potential diagnostic and prognostic benefits of a layer-specific approach. For this prospective study patients in the emergency department fulfilling rule-in criteria for non-ST-elevation myocardial infarction (NSTEMI) received an ultra-fast fSENC CMR. Volunteers without cardiac diseases (controls) were recruited for comparison. Measurements were performed in a single heartbeat acquisition to measure global and segmental longitudinal strain (GLS) and dysfunctional segments. The GLS was measured in two layers and a difference (GLS 114 participants, including 50 controls were included. The 64 patients (51 male) were divided into a NSTEMI (25), myocarditis (16) and other myocardial injury group (23). GLS served as a potent predictor of myocardial injury (area under the curve (AUC) 91.8%). The GLS Layer-specific strain is a potential new marker with high diagnostic performance in the identification and differentiation of acute myocardial injuries.
Sections du résumé
BACKGROUND
BACKGROUND
Acute myocardial injury is a common diagnosis in the emergency department and differential diagnoses are numerous. Cardiac magnetic resonance (CMR) strain sequences like fSENC are early predictors of myocardial function loss. This study assessed the potential diagnostic and prognostic benefits of a layer-specific approach.
METHODS
METHODS
For this prospective study patients in the emergency department fulfilling rule-in criteria for non-ST-elevation myocardial infarction (NSTEMI) received an ultra-fast fSENC CMR. Volunteers without cardiac diseases (controls) were recruited for comparison. Measurements were performed in a single heartbeat acquisition to measure global and segmental longitudinal strain (GLS) and dysfunctional segments. The GLS was measured in two layers and a difference (GLS
RESULTS
RESULTS
114 participants, including 50 controls were included. The 64 patients (51 male) were divided into a NSTEMI (25), myocarditis (16) and other myocardial injury group (23). GLS served as a potent predictor of myocardial injury (area under the curve (AUC) 91.8%). The GLS
CONCLUSIONS
CONCLUSIONS
Layer-specific strain is a potential new marker with high diagnostic performance in the identification and differentiation of acute myocardial injuries.
Identifiants
pubmed: 38244931
pii: S1097-6647(24)00992-X
doi: 10.1016/j.jocmr.2024.101001
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101001Informations de copyright
Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Lukas Weberling reports equipment, drugs, or supplies was provided by Myocardial Solutions Inc. Lukas Weberling reports article publishing charges was provided by German Research Foundation. Lukas Weberling reports financial support was provided by German Center for Cardiovascular Disease. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper Competing interests The authors declare that they have no competing interests.