Three immunizations with Novavax's protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2.


Journal

NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863

Informations de publication

Date de publication:
20 Jan 2024
Historique:
received: 04 07 2023
accepted: 08 12 2023
medline: 21 1 2024
pubmed: 21 1 2024
entrez: 20 1 2024
Statut: epublish

Résumé

The immune responses to Novavax's licensed NVX-CoV2373 nanoparticle Spike protein vaccine against SARS-CoV-2 remain incompletely understood. Here, we show in rhesus macaques that immunization with Matrix-M

Identifiants

pubmed: 38245545
doi: 10.1038/s41541-024-00806-2
pii: 10.1038/s41541-024-00806-2
doi:

Types de publication

Journal Article

Langues

eng

Pagination

17

Subventions

Organisme : EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)
ID : 101003653

Informations de copyright

© 2024. The Author(s).

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Auteurs

Klara Lenart (K)

Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden.
Karolinska University Hospital, Stockholm, Sweden.
Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

Rodrigo Arcoverde Cerveira (R)

Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden.
Karolinska University Hospital, Stockholm, Sweden.
Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

Fredrika Hellgren (F)

Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden.
Karolinska University Hospital, Stockholm, Sweden.
Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

Sebastian Ols (S)

Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden.
Karolinska University Hospital, Stockholm, Sweden.
Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

Daniel J Sheward (DJ)

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

Changil Kim (C)

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

Alberto Cagigi (A)

Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden.
Karolinska University Hospital, Stockholm, Sweden.
Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

Matthew Gagne (M)

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Brandon Davis (B)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.

Daritza Germosen (D)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.

Vicky Roy (V)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.

Galit Alter (G)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.

Hélène Letscher (H)

Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.

Jérôme Van Wassenhove (J)

Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.

Wesley Gros (W)

Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.

Anne-Sophie Gallouët (AS)

Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.

Roger Le Grand (R)

Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses & Le Kremlin-Bicêtre, Paris, France.

Harry Kleanthous (H)

Bill & Melinda Gates Foundation, Seattle, WA, USA.
SK Biosciences, Boston, MA, USA.

Mimi Guebre-Xabier (M)

Novavax Inc, Gaithersburg, MD, USA.

Ben Murrell (B)

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

Nita Patel (N)

Novavax Inc, Gaithersburg, MD, USA.

Gregory Glenn (G)

Novavax Inc, Gaithersburg, MD, USA.

Gale Smith (G)

Novavax Inc, Gaithersburg, MD, USA.

Karin Loré (K)

Department of Medicine Solna, Division of Immunology and Allergy, Karolinska Institutet, Stockholm, Sweden. karin.lore@ki.se.
Karolinska University Hospital, Stockholm, Sweden. karin.lore@ki.se.
Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. karin.lore@ki.se.

Classifications MeSH