Crystallization from solution versus mechanochemistry to obtain double-drug multicomponent crystals of ethacridine with salicylic/acetylsalicylic acids.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 Jan 2024
21 Jan 2024
Historique:
received:
25
09
2023
accepted:
13
12
2023
medline:
22
1
2024
pubmed:
22
1
2024
entrez:
21
1
2024
Statut:
epublish
Résumé
Salicylic and acetylsalicylic acids and ethacridine have complementary bioactive properties. They can be combined to obtain double-drug multicomponent crystals. Their reactivity in different environments was explored to obtain the possible compounds, stable at different hydration degrees. Solution, liquid-assisted grinding, and dry preparation approaches were applied to the couples of reactants in different stoichiometric ratios. Four compounds were obtained, and three out of them were stable and reproducible enough to determine their structures using SCXRD or PXRD methods. When coupled to ethacridine, salicylic acid gave two stable structures (1 and 3, both showing 1:1 ratio but different hydration degree) and a metastable one (5), while acetylsalicylic acid only one structure from solution (2 in 1:1 ratio), while LAG caused hydrolysis and formation of the same compound obtained by LAG of ethacridine with salicylic acid. While solution precipitation gave dihydrated (1) or monohydrated (2) structures with low yields, LAG of salicylic acid and ethacridine allowed obtaining an anhydrous salt complex (3) with a yield close to 1. The structures obtained by solution crystallizations maximize π
Identifiants
pubmed: 38246926
doi: 10.1038/s41598-023-49922-4
pii: 10.1038/s41598-023-49922-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1834Subventions
Organisme : Uniwersytet Gdański
ID : 539-T080-B055-23
Organisme : Uniwersytet Gdański
ID : 530-8228-D738-23
Informations de copyright
© 2024. The Author(s).
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