Naturally Derived Phenethyl Isothiocyanate Modulates Induction of Oxidative Stress via Its

antioxidant enzymes isothiocyanates malignant melanoma mercapturic acid pathway oxidative stress phenethyl isothiocyanate polyphenols watercress

Journal

Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981

Informations de publication

Date de publication:
08 Jan 2024
Historique:
received: 12 12 2023
revised: 04 01 2024
accepted: 05 01 2024
medline: 22 1 2024
pubmed: 22 1 2024
entrez: 22 1 2024
Statut: epublish

Résumé

Phenethyl isothiocyanate (PEITC) is a secondary metabolic product yielded upon the hydrolysis of gluconasturtiin and it is highly accumulated in the flowers of watercress. The aim of the current study was to assess the role of a naturally derived PEITC-enriched extract in the induction of oxidative stress and to evaluate its anti-melanoma potency through the regulation of its metabolism with the concurrent production of the

Identifiants

pubmed: 38247506
pii: antiox13010082
doi: 10.3390/antiox13010082
pii:
doi:

Types de publication

Journal Article

Langues

eng

Auteurs

Sotiris Kyriakou (S)

Department of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, Nicosia 2371, Cyprus.

Nikoletta Demosthenous (N)

Department of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, Nicosia 2371, Cyprus.

Tom Amery (T)

The Watercress Company, Dorchester DT2 8QY, UK.

Kyle J Stewart (KJ)

Watercress Research Limited, Unit 24, De Havilland Road, Exeter EX5 2GE, UK.

Paul G Winyard (PG)

Watercress Research Limited, Unit 24, De Havilland Road, Exeter EX5 2GE, UK.

Rodrigo Franco (R)

Redox Biology Centre, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Department of Veterinary Medicine & Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.

Aglaia Pappa (A)

Department of Molecular Biology & Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece.

Mihalis I Panayiotidis (MI)

Department of Cancer Genetics, Therapeutics & Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, Nicosia 2371, Cyprus.

Classifications MeSH