A low-dose thrombolytic infusion protocol for safe and successful treatment of left ventricular assist device thrombosis: a case series.
Case series
Complications
LVAD thrombosis
Thrombolytic
Journal
European heart journal. Case reports
ISSN: 2514-2119
Titre abrégé: Eur Heart J Case Rep
Pays: England
ID NLM: 101730741
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
received:
27
02
2023
revised:
04
12
2023
accepted:
02
01
2024
medline:
22
1
2024
pubmed:
22
1
2024
entrez:
22
1
2024
Statut:
epublish
Résumé
Pump thrombosis is a serious complication of continuous-flow left ventricular assist device (CF-LVAD) therapy. In this study, we aim to report a novel protocol of an intermittent, low-dose, and slow infusion of tissue plasminogen activator (alteplase). We treated seven LVAD pump thrombosis events (HeartMate A low-dose, prolonged, and systemic thrombolytic infusion protocol is an effective and relatively safe treatment that can lead to a sustained resolution of pump thrombosis with low bleeding complications and failure rates.
Sections du résumé
Background
UNASSIGNED
Pump thrombosis is a serious complication of continuous-flow left ventricular assist device (CF-LVAD) therapy. In this study, we aim to report a novel protocol of an intermittent, low-dose, and slow infusion of tissue plasminogen activator (alteplase).
Case summary
UNASSIGNED
We treated seven LVAD pump thrombosis events (HeartMate
Discussion
UNASSIGNED
A low-dose, prolonged, and systemic thrombolytic infusion protocol is an effective and relatively safe treatment that can lead to a sustained resolution of pump thrombosis with low bleeding complications and failure rates.
Identifiants
pubmed: 38249117
doi: 10.1093/ehjcr/ytae001
pii: ytae001
pmc: PMC10799658
doi:
Types de publication
Case Reports
Langues
eng
Pagination
ytae001Informations de copyright
© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.
Déclaration de conflit d'intérêts
Conflict of interest: A.A., R.G., M.W.C., V.C., S.L., W.I. K., and K.C. declare no conflict of interest. ‘All authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.’