Ferredoxin 1 is essential for embryonic development and lipid homeostasis.
cancer biology
mouse
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
22 Jan 2024
22 Jan 2024
Historique:
received:
06
08
2023
accepted:
19
01
2024
medline:
22
1
2024
pubmed:
22
1
2024
entrez:
22
1
2024
Statut:
aheadofprint
Résumé
Mammalian ferredoxin 1 and 2 (FDX1/2) belong to an evolutionary conserved family of iron-sulfur cluster containing proteins and act as electron shutters between ferredoxin reductase (FDXR) and numerous proteins involved in critical biological pathways. FDX1 is involved in biogenesis of steroids and bile acids, Vitamin A/D metabolism, and lipoylation of tricarboxylic acid (TCA) cycle enzymes. FDX1 has been extensively characterized biochemically but its role in physiology and lipid metabolism has not been explored. In this study, we generated
Identifiants
pubmed: 38251655
doi: 10.7554/eLife.91656
pii: 91656
doi:
pii:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : CA224433
Pays : United States
Informations de copyright
© 2024, Mohibi et al.
Déclaration de conflit d'intérêts
SM, YZ, VP, MC, JZ, XC The authors declare that no competing interests exist.