Therapeutic importance and diagnostic function of circRNAs in urological cancers: from metastasis to drug resistance.

Bladder cancer CircRNAs Exosomes Non-coding RNAs Prostate cancer Renal cancer

Journal

Cancer metastasis reviews
ISSN: 1573-7233
Titre abrégé: Cancer Metastasis Rev
Pays: Netherlands
ID NLM: 8605731

Informations de publication

Date de publication:
22 Jan 2024
Historique:
received: 10 06 2023
accepted: 31 10 2023
medline: 22 1 2024
pubmed: 22 1 2024
entrez: 22 1 2024
Statut: aheadofprint

Résumé

Circular RNAs (circRNAs) are a member of non-coding RNAs with no ability in encoding proteins and their aberrant dysregulation is observed in cancers. Their closed-loop structure has increased their stability, and they are reliable biomarkers for cancer diagnosis. Urological cancers have been responsible for high mortality and morbidity worldwide, and developing new strategies in their treatment, especially based on gene therapy, is of importance since these malignant diseases do not respond to conventional therapies. In the current review, three important aims are followed. At the first step, the role of circRNAs in increasing or decreasing the progression of urological cancers is discussed, and the double-edged sword function of them is also highlighted. At the second step, the interaction of circRNAs with molecular targets responsible for urological cancer progression is discussed, and their impact on molecular processes such as apoptosis, autophagy, EMT, and MMPs is highlighted. Finally, the use of circRNAs as biomarkers in the diagnosis and prognosis of urological cancer patients is discussed to translate current findings in the clinic for better treatment of patients. Furthermore, since circRNAs can be transferred to tumor via exosomes and the interactions in tumor microenvironment provided by exosomes such as between macrophages and cancer cells is of importance in cancer progression, a separate section has been devoted to the role of exosomal circRNAs in urological tumors.

Identifiants

pubmed: 38252399
doi: 10.1007/s10555-023-10152-9
pii: 10.1007/s10555-023-10152-9
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Auteurs

Zhibin Zhang (Z)

College of Traditional Chinese Medicine, Chengde Medical College, Chengde, 067000, Hebei, China. zzb_1985@cdmc.edu.cn.

Zhixu Gao (Z)

Chengde Medical College, Chengde, 067000, Hebei, China.

Huimin Fang (H)

Chengde Medical College, Chengde, 067000, Hebei, China.

Yutang Zhao (Y)

Chengde Medical College, Chengde, 067000, Hebei, China.

Rong Xing (R)

Chengde Medical College, Chengde, 067000, Hebei, China.

Classifications MeSH