Disulfide bridge-dependent dimerization triggers FGF2 membrane translocation into the extracellular space.
E. coli
FGF2
Protein trafficking
Protein-lipid interaction
Protein-protein interaction
Unconventional protein secretion
biochemistry
chemical biology
cho
cho k1
hela s3
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
22 Jan 2024
22 Jan 2024
Historique:
medline:
23
1
2024
pubmed:
22
1
2024
entrez:
22
1
2024
Statut:
epublish
Résumé
Fibroblast growth factor 2 (FGF2) exits cells by direct translocation across the plasma membrane, a type I pathway of unconventional protein secretion. This process is initiated by phosphatidylinositol-4,5-bisphosphate (PI(4,5)P
Identifiants
pubmed: 38252473
doi: 10.7554/eLife.88579
pii: 88579
doi:
pii:
Substances chimiques
Fibroblast Growth Factor 2
103107-01-3
Sodium-Potassium-Exchanging ATPase
EC 7.2.2.13
Disulfides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : DFG LO 2821/1-1
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB/TRR 186 project A1
Organisme : Deutsche Forschungsgemeinschaft
ID : DFG Ni 423/10-1
Organisme : Deutsche Forschungsgemeinschaft
ID : DFG Ni 423/12-1
Organisme : Deutsche Forschungsgemeinschaft
ID : DFG Ni 423/13-1
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB/TRR 186 project A5
Organisme : Grantová Agentura České Republiky
ID : 20-01401
Organisme : Deutsche Forschungsgemeinschaft
ID : INST 35/1314-1 FUGG
Organisme : Deutsche Forschungsgemeinschaft
ID : INST 35/1503-1 FUGG
Organisme : Academy of Finland
ID : 331349
Organisme : Academy of Finland
ID : 336234
Organisme : Academy of Finland
ID : 346135
Organisme : Human Frontier Science Program
ID : RGP0059/2019
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB/TRR 83
Organisme : HORIZON EUROPE Marie Sklodowska-Curie Actions
ID : 101033606
Informations de copyright
© 2023, Lolicato, Steringer et al.
Déclaration de conflit d'intérêts
FL, JS, RS, DB, JF, SU, SK, PR, SW, HM, XS, SK, CF, MH, RŠ, PC, IV, WN No competing interests declared
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