Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins.

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
22 Jan 2024
Historique:
medline: 22 1 2024
pubmed: 22 1 2024
entrez: 22 1 2024
Statut: aheadofprint

Résumé

The suppressor of T cell receptor signaling (Sts) proteins are negative regulators of immune signaling. Genetic inactivation of these proteins leads to significant resistance to infection. From a 590,000 compound high-throughput screen, we identified the 2-(

Identifiants

DOI: 10.1021/acs.jmedchem.3c01763 PMID: 38252624
pubmed: 38252624
doi: 10.1021/acs.jmedchem.3c01763
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Faisal Aziz (F)

The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, United States.

Kanamata Reddy (K)

The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, United States.

Virneliz Fernandez Vega (V)

Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute, Jupiter, Florida 33458, United States.

Raja Dey (R)

The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, United States.

Katherine A Hicks (KA)

Department of Chemistry, State University of New York at Cortland, Cortland, New York 13045, United States.
ORCID: 0000-0002-1474-1067

Sumitha Rao (S)

Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute, Jupiter, Florida 33458, United States.

Luis Ortiz Jordan (LO)

Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute, Jupiter, Florida 33458, United States.

Emery Smith (E)

Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute, Jupiter, Florida 33458, United States.

Justin Shumate (J)

Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute, Jupiter, Florida 33458, United States.

Louis Scampavia (L)

Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute, Jupiter, Florida 33458, United States.

Nicholas Carpino (N)

Department of Microbiology and Immunology, Stony Brook University, Stony Brook, New York 11790, United States.

Timothy P Spicer (TP)

Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute, Jupiter, Florida 33458, United States.

Jarrod B French (JB)

The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, United States.
ORCID: 0000-0002-6762-1309

Classifications MeSH