Amino acid and protein specificity of protein fatty acylation in

C. elegans branched-chain fatty acids click chemistry protein lipidation proteomics

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
30 Jan 2024
Historique:
medline: 22 1 2024
pubmed: 22 1 2024
entrez: 22 1 2024
Statut: ppublish

Résumé

Protein lipidation plays critical roles in regulating protein function and localization. However, the chemical diversity and specificity of fatty acyl group utilization have not been investigated using untargeted approaches, and it is unclear to what extent structures and biosynthetic origins of

Identifiants

pubmed: 38252833
doi: 10.1073/pnas.2307515121
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2307515121

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM131877
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA240529
Pays : United States

Déclaration de conflit d'intérêts

Competing interests statement:H.L. is a founder of, consultant, and a stockholder for Sedec Therapeutics. F.C.S. is a founder of, consultant, and a stockholder for Ascribe Bioscience and Holoclara Inc.

Auteurs

Bingsen Zhang (B)

Boyce Thompson Institute, Cornell University, Ithaca, NY 14853.
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.

Yan Yu (Y)

Boyce Thompson Institute, Cornell University, Ithaca, NY 14853.
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.

Bennett W Fox (BW)

Boyce Thompson Institute, Cornell University, Ithaca, NY 14853.
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.

Yinong Liu (Y)

Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.

Venkatesh P Thirumalaikumar (VP)

Boyce Thompson Institute, Cornell University, Ithaca, NY 14853.

Aleksandra Skirycz (A)

Boyce Thompson Institute, Cornell University, Ithaca, NY 14853.

Hening Lin (H)

Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
HHMI, Cornell University, Ithaca, NY 14853.
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853.

Frank C Schroeder (FC)

Boyce Thompson Institute, Cornell University, Ithaca, NY 14853.
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.

Classifications MeSH