Effectiveness of omalizumab across different dosing regimens in patients with moderate-to-severe allergic asthma.

For patients with moderate-to-severe persistent allergic asthma, omalizumab is approved for subcutaneous administration according to a recommended dosing table based on weight and total immunoglobulin E (IgE) level. The aim of this analysis was to assess asthma outcomes including quality of life in patients with allergic asthma initiated on omalizumab in the PROSPERO trial; patients were stratified by where their IgE and body weight fell on the approved dosing table. Patient groups were defined as Inside Dosing Table: patients whose IgE and weight fell within the approved dosing table (n = 506); Insufficient Data to Recommend a Dose: patients who fell into the section of the approved dosing table where not enough clinical data were available to make dosing recommendations (n = 72); and Outside Dosing Table: patients who fell outside the approved dosing table due to baseline IgE and/or weight (n = 209). Overall, asthma and quality of life outcomes were improved after omalizumab initiation for both patients who fall within the recommended dosing table or those who fall outside the recommended dosing table. Our results suggest that omalizumab treatment may be effective in a wide range of patients with moderate-to-severe allergic asthma. ClinicalTrials.gov identifier NCT01922037.

Informations de copyright

Copyright © 2024. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of competing interest NMC: consultant and/or speaker bureau member for Amgen, ARS Pharmaceuticals Inc., AstraZeneca, Blueprint Medicines, Bryn Pharma, Genentech Inc., GlaxoSmithKline, Hikma Pharmaceuticals, Incyte, Novartis, Regeneron, and Sanofi; speaker bureau member for Incyte; consultant for ARS Pharmaceuticals Inc., Bryn Pharma, Genentech, Inc., Hikma Pharmaceuticals, and Novartis Pharmaceuticals Corporation. ML: institution received research grant support on her behalf from Sanofi; received honoraria for serving as a consultant for AstraZeneca. CTJH: former employee of Genentech, Inc. LAM, AS, JWS, BLT: employees of Genentech, Inc.; stockholders of Roche. NAH: received honoraria for serving as advisor or consultant for Amgen, AstraZeneca, Genentech, Inc., GlaxoSmithKline, Novartis Pharmaceuticals Corporation, Regeneron, Sanofi, and Teva. Institution received research grant support on his behalf from AstraZeneca, Genentech, Inc., GlaxoSmithKline, Novartis, Sanofi, and Teva. TBC: consultant and speaker bureau member for Genentech, Inc.; consultant for Novartis Pharmaceuticals Corporation; chief medical advisor for Food Allergy Research & Education.