State-of-the-art drug delivery system to target the lymphatics.

The lymphatic system assumes a pivotal role in maintaining humoral equilibrium, regulating lipid metabolism, and orchestrating immune responses. Lymph nodes (LNs) are recognized as primary loci for tumor metastasis, significantly impacting patient prognosis. The strategic development of lymphatic-targeted systems holds promise for both disease treatment and vaccination effectiveness. In recent years, the convergence of nanotechnologies and innovative biomaterials has garnered substantial interest in crafting lymphatic-targeted drug delivery systems. Leveraging endogenous macromolecules mimicking structural orientation, these nanocarriers exhibit considerable potential in disease diagnosis and tumor therapy. This review commences with an exploration of the physiological functions of lymphatic system and role in various diseases, followed by a comprehensive survey of prominent lymphatic-targeted nanomaterial-based drug delivery systems, encompassing liposomes, micelles, inorganic nanomaterials, hydrogels, and nano-capsules. The narrative concludes by presenting future perspectives and summarizing key insights pertaining to lymphatic -targeted drug delivery systems.