Cell-Free Genic Extrachromosomal Circular DNA Profiles of DNase Knockouts Associated with Systemic Lupus Erythematosus and Relation with Common Fragile Sites.
DifCir
Dnase1
Dnase1l3
buffy coat
chromosomal fragile site (CFS)
differentially produced per gene circle (DPpGC)
extrachromosomal circular DNA (eccDNA)
genome-wide association study (GWAS)
liver
plasma
produced per gene circle (PpGC)
systemic lupus erythematosus (SLE)
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
28 Dec 2023
28 Dec 2023
Historique:
received:
28
11
2023
revised:
25
12
2023
accepted:
26
12
2023
medline:
23
1
2024
pubmed:
23
1
2024
entrez:
23
1
2024
Statut:
epublish
Résumé
Cell-free extrachromosomal circular DNA (cf-eccDNA) has been proposed as a promising early biomarker for disease diagnosis, progression and drug response. Its established biomarker features are changes in the number and length distribution of cf-eccDNA. Another novel promising biomarker is a set of eccDNA excised from a panel of genes specific to a condition compared to a control. Deficiencies in two endonucleases that specifically target DNA, Dnase1 and Dnase1l3, are associated with systemic lupus erythematosus (SLE). To study the genic eccDNA profiles in the case of their deficiencies, we mapped sequenced eccDNA data from plasma, liver and buffy coat from
Identifiants
pubmed: 38255187
pii: biomedicines12010080
doi: 10.3390/biomedicines12010080
pii:
doi:
Types de publication
Journal Article
Langues
eng