Rats Selected for Different Nervous Excitability: Long-Term Emotional-Painful Stress Affects the Dynamics of DNA Damage in Cells of Several Brain Areas.
DNA damage
PTSD
amygdala
comet assay
compulsive disorder
hippocampus
nervous system excitability
prefrontal cortex
rats
stress
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Jan 2024
13 Jan 2024
Historique:
received:
14
12
2023
revised:
05
01
2024
accepted:
11
01
2024
medline:
23
1
2024
pubmed:
23
1
2024
entrez:
23
1
2024
Statut:
epublish
Résumé
The maintenance of genome stability is critical for health, but during individual ontogenesis, different stressors affect DNA integrity, which can lead to functional and/or structural changes in the cells of target organs. In the nervous system, cell genome destabilization is associated with different neurological and psychiatric diseases, but experiments in vivo, where a link between stress and DNA instability has been demonstrated, are relatively rare. Here, we use rat strains selected for the contrast excitability of the tibialis nerve (
Identifiants
pubmed: 38256068
pii: ijms25020994
doi: 10.3390/ijms25020994
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : State Program 47 "Scientific and Technological Development of the Russian Federation" (2019-2030)
ID : theme reg. no. 0134-2019-0002