Design, Synthesis, and Biological Evaluation of 2-Substituted Aniline Pyrimidine Derivatives as Potent Dual Mer/c-Met Inhibitors.

2-substituted aniline pyrimidine Mer kinase anticancer c-Met kinase dual inhibitor

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
18 Jan 2024
Historique:
received: 06 12 2023
revised: 04 01 2024
accepted: 13 01 2024
medline: 23 1 2024
pubmed: 23 1 2024
entrez: 23 1 2024
Statut: epublish

Résumé

Mer and c-Met kinases, which are commonly overexpressed in various tumors, are ideal targets for the development of antitumor drugs. This study focuses on the design, synthesis, and evaluation of several 2-substituted aniline pyrimidine derivatives as highly potent dual inhibitors of Mer and c-Met kinases for effective tumor treatment. Compound

Identifiants

DOI: 10.3390/molecules29020475 PMID: 38257391
pubmed: 38257391
pii: molecules29020475
doi: 10.3390/molecules29020475
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Natural Science Foundation of China
ID : 82003601
Organisme : Initial Research Project of High Level Talent in Hebei University of Chinese Medicine
ID : 1020103022

Auteurs

Daowei Huang (D)

School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China.
State Key Laboratory Breeding Base-Hebei Key Laboratory of Molecular Chemistry for Drug, Shijiazhuang 050018, China.

Ying Chen (Y)

School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China.

Jixia Yang (J)

School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang 050200, China.

Bingyang Zhao (B)

School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China.

Shouying Wang (S)

School of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang 050018, China.

Tingting Chai (T)

School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China.

Jie Cui (J)

Department of Head and Neck Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China.

Xiaolei Zhou (X)

School of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang 050018, China.

Zhenhua Shang (Z)

School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China.
State Key Laboratory Breeding Base-Hebei Key Laboratory of Molecular Chemistry for Drug, Shijiazhuang 050018, China.

Classifications MeSH