Drug Resistance and Molecular Characteristics of Carbapenem-Resistant OXA-48-Producing
Klebsiella pneumoniae
OXA-48
carbapenemase
hypervirulent strain
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
27 Dec 2023
27 Dec 2023
Historique:
received:
24
11
2023
revised:
11
12
2023
accepted:
22
12
2023
medline:
23
1
2024
pubmed:
23
1
2024
entrez:
23
1
2024
Statut:
epublish
Résumé
The emergence and global spread of carbapenem-resistant hypervirulent OXA-48-producing hvKP strains were collected from clinical specimens at the First Affiliated Hospital of Hainan Medical University from January 2022 to March 2023. Hypervirulent strains were tested for virulence in a mouse lethality study and underwent whole genome sequencing to identify genomic features. A total of 42 unique OXA-48-bearing Our study highlighted the two evolutionary pathways of OXA-48-producing hvKP strains and confirmed their virulence through in vivo testing. Ceftazidime/avibactam may be a viable option for treating OXA-48-producing hvKP strains.
Sections du résumé
BACKGROUND
BACKGROUND
The emergence and global spread of carbapenem-resistant hypervirulent
METHODS
METHODS
OXA-48-producing hvKP strains were collected from clinical specimens at the First Affiliated Hospital of Hainan Medical University from January 2022 to March 2023. Hypervirulent strains were tested for virulence in a mouse lethality study and underwent whole genome sequencing to identify genomic features.
RESULTS
RESULTS
A total of 42 unique OXA-48-bearing
CONCLUSIONS
CONCLUSIONS
Our study highlighted the two evolutionary pathways of OXA-48-producing hvKP strains and confirmed their virulence through in vivo testing. Ceftazidime/avibactam may be a viable option for treating OXA-48-producing hvKP strains.
Identifiants
pubmed: 38257876
pii: microorganisms12010049
doi: 10.3390/microorganisms12010049
pii:
doi:
Types de publication
Journal Article
Langues
eng