Moderate variations in the human diet impact the gut microbiota in humanized mice.
diet intervention
fecal microbiota transfer
germ-free mice
gnotobiotic mice
gut microbiota
humanized mice
Journal
Acta physiologica (Oxford, England)
ISSN: 1748-1716
Titre abrégé: Acta Physiol (Oxf)
Pays: England
ID NLM: 101262545
Informations de publication
Date de publication:
22 Jan 2024
22 Jan 2024
Historique:
revised:
10
10
2023
received:
17
08
2023
accepted:
01
01
2024
medline:
23
1
2024
pubmed:
23
1
2024
entrez:
23
1
2024
Statut:
aheadofprint
Résumé
Drastic diet interventions have been shown to promote rapid and significant compositional changes of the gut microbiota, but the impact of moderate diet variations is less clear. Here, we aimed to clarify the impact of moderate diet variations that remain within the spectrum of the habitual human diet on gut microbiota composition. We performed a pilot diet intervention where five healthy volunteers consumed a vegetarian ready-made meal for three days to standardize dietary intake before switching to a meat-based ready-made western-style meal and high sugar drink for two days. We performed 16S rRNA sequencing from daily fecal sampling to assess gut microbiota changes caused by the intervention diet. Furthermore, we used the volunteers' fecal samples to colonize germ-free mice that were fed the same sterilized diets to study the effect of a moderate diet intervention on the gut microbiota in a setting of reduced interindividual variation. In the human intervention, we found that fecal microbiota composition varied between and within individuals regardless of diet. However, when we fed the same diets to mice colonized with the study participants' feces, we observed significant, often donor-specific, changes in the mouse microbiota following this moderate diet intervention. Moderate variations in the habitual human diet have the potential to alter the gut microbiota. Feeding humanized mice human diets may facilitate our understanding of individual human gut microbiota responses to moderate dietary changes and help improve individualized interventions.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14100Subventions
Organisme : Vetenskapsrådet
Organisme : Joint Programming Initiative A healthy diet for a healthy life
Organisme : Transatlantic Networks of Excellence Award from the Leducq Foundation
Organisme : AFA insurances
Organisme : HjärtLungfonden
Organisme : Knut och Alice Wallenbergs Stiftelse
Organisme : ALFagreement
Informations de copyright
© 2024 The Authors. Acta Physiologica published by John Wiley & Sons Ltd on behalf of Scandinavian Physiological Society.
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