Neuropathy in ARSACS is demyelinating but without typical nerve enlargement in nerve ultrasound.

ARSACS Ataxia Neuropathy UPSS Ultrasound

Journal

Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161

Informations de publication

Date de publication:
23 Jan 2024
Historique:
received: 08 10 2023
accepted: 12 12 2023
revised: 11 12 2023
medline: 23 1 2024
pubmed: 23 1 2024
entrez: 23 1 2024
Statut: aheadofprint

Résumé

To specify peripheral nerve affection in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) by correlating high-resolution nerve ultrasound and nerve conduction studies. We assessed a cohort of 11 ARSACS patients with standardized nerve conduction studies and high-resolution ultrasound of peripheral nerves and compared nerve ultrasound findings to a healthy control group matched for age, sex, size and weight. Mean age of patients was 39.0 (± 14.1) years and disease duration at assessment 30.6 (± 12.5) years. All patients presented with a spasticity, ataxia and peripheral neuropathy. Neuropathy appeared to be primarily demyelinating in 9/11 cases and was not classifiable in 2/11 cases due to not evocable potentials. Nerve ultrasound revealed a normal ultrasound pattern sum score (UPSS) in each ARSACS patient and no significant nerve enlargement compared to the control group. Peripheral neuropathy in ARSACS showed primarily demyelinating rather than axonal characteristics and presented without nerve enlargement. As demyelinating neuropathies do commonly present enlarged nerves we recommend further genetic testing of the SACS gene in patients who present with this combination of demyelinating neuropathy without nerve enlargement. ARSACS cases that initially presented only with neuropathy without spasticity or ataxia and therefore were misdiagnosed as Charcot-Marie-Tooth disease are supporting this suggestion.

Sections du résumé

BACKGROUND BACKGROUND
To specify peripheral nerve affection in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) by correlating high-resolution nerve ultrasound and nerve conduction studies.
METHODS METHODS
We assessed a cohort of 11 ARSACS patients with standardized nerve conduction studies and high-resolution ultrasound of peripheral nerves and compared nerve ultrasound findings to a healthy control group matched for age, sex, size and weight.
RESULTS RESULTS
Mean age of patients was 39.0 (± 14.1) years and disease duration at assessment 30.6 (± 12.5) years. All patients presented with a spasticity, ataxia and peripheral neuropathy. Neuropathy appeared to be primarily demyelinating in 9/11 cases and was not classifiable in 2/11 cases due to not evocable potentials. Nerve ultrasound revealed a normal ultrasound pattern sum score (UPSS) in each ARSACS patient and no significant nerve enlargement compared to the control group.
CONCLUSIONS CONCLUSIONS
Peripheral neuropathy in ARSACS showed primarily demyelinating rather than axonal characteristics and presented without nerve enlargement. As demyelinating neuropathies do commonly present enlarged nerves we recommend further genetic testing of the SACS gene in patients who present with this combination of demyelinating neuropathy without nerve enlargement. ARSACS cases that initially presented only with neuropathy without spasticity or ataxia and therefore were misdiagnosed as Charcot-Marie-Tooth disease are supporting this suggestion.

Identifiants

pubmed: 38261029
doi: 10.1007/s00415-023-12159-2
pii: 10.1007/s00415-023-12159-2
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Katharina Kneer (K)

Department of Epileptology, Center of Neurology, Universitätsklinikum Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany. katharina.kneer@med.uni-tuebingen.de.
Hertie Institute for Clinical Brain Research, Eberhard-Karls University Tübingen, Tübingen, Germany. katharina.kneer@med.uni-tuebingen.de.

Stephanie Straub (S)

Department of Epileptology, Center of Neurology, Universitätsklinikum Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.
Hertie Institute for Clinical Brain Research, Eberhard-Karls University Tübingen, Tübingen, Germany.

Julia Wittlinger (J)

Department of Epileptology, Center of Neurology, Universitätsklinikum Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.
Hertie Institute for Clinical Brain Research, Eberhard-Karls University Tübingen, Tübingen, Germany.

Jan-Hendrik Stahl (JH)

Department of Epileptology, Center of Neurology, Universitätsklinikum Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.
Hertie Institute for Clinical Brain Research, Eberhard-Karls University Tübingen, Tübingen, Germany.

Natalie Winter (N)

Department of Epileptology, Center of Neurology, Universitätsklinikum Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.
Hertie Institute for Clinical Brain Research, Eberhard-Karls University Tübingen, Tübingen, Germany.

Dagmar Timmann (D)

Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Essen University Hospital, University of Duisburg-Essen, Essen, Germany.

Ludger Schöls (L)

Hertie Institute for Clinical Brain Research, Eberhard-Karls University Tübingen, Tübingen, Germany.
Department of Neurodegenerative Diseases, Center of Neurology, University of Tuebingen, Tuebingen, Germany.
German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.

Matthis Synofzik (M)

Hertie Institute for Clinical Brain Research, Eberhard-Karls University Tübingen, Tübingen, Germany.
Department of Neurodegenerative Diseases, Center of Neurology, University of Tuebingen, Tuebingen, Germany.
German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.

Friedemann Bender (F)

Department of Neurodegenerative Diseases, Center of Neurology, University of Tuebingen, Tuebingen, Germany.
Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Essen University Hospital, University of Duisburg-Essen, Essen, Germany.
German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.
Kinder- Und Jugend Psychiatrie Klink Esslingen, Esslingen, Germany.

Alexander Grimm (A)

Department of Epileptology, Center of Neurology, Universitätsklinikum Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.
Hertie Institute for Clinical Brain Research, Eberhard-Karls University Tübingen, Tübingen, Germany.

Classifications MeSH