Characterising B cell expression and prognostic significance in human papillomavirus positive oropharyngeal cancer.

B cells CD20 Human papillomavirus Oropharyngeal cancer Prognosis Tertiary lymphoid structures

Journal

Oral oncology
ISSN: 1879-0593
Titre abrégé: Oral Oncol
Pays: England
ID NLM: 9709118

Informations de publication

Date de publication:
22 Jan 2024
Historique:
received: 02 11 2023
revised: 20 12 2023
accepted: 07 01 2024
medline: 24 1 2024
pubmed: 24 1 2024
entrez: 23 1 2024
Statut: aheadofprint

Résumé

The incidence of human papillomavirus positive oropharyngeal cancer (HPV+OPC) is increasing, and new biomarkers are required to better define prognostic groups and guide treatment. Infiltrating T cells have been well studied in head and neck cancer, however the presence and role of B cells and tertiary lymphoid structures (TLS) in the tumor microenvironment has not, even though the interplay between T and B cells is increasingly being recognised. Using CD20 immunohistochemistry (IHC) to identify B cells and TLS in a cohort of 159 HPV + OPC patients, we semi-quantitatively scored abundance and location (intra-tumoral or stromal) and correlated findings with patient survival. 32% (51/157) of patients had high intra-tumoral (IT) abundance of CD20 CD20

Identifiants

DOI: 10.1016/j.oraloncology.2024.106687 PMID: 38262249
pubmed: 38262249
pii: S1368-8375(24)00005-8
doi: 10.1016/j.oraloncology.2024.106687
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106687

Informations de copyright

Copyright © 2024 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Richard J Young (RJ)

Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia.

Christopher Angel (C)

Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Australia.

Mathias Bressel (M)

Centre for Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, Melbourne, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.

Angela Pizzolla (A)

Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia.

Alesha A Thai (AA)

Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.

Sandro V Porceddu (SV)

Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, Australia; Faculty of Medicine, University of Queensland, Brisbane, Australia.

Howard Liu (H)

Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, Australia; Faculty of Medicine, University of Queensland, Brisbane, Australia.

Rejhan Idrizi (R)

Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia; Centre for Advanced Histology and Microscopy, Peter MacCallum Cancer Centre, Melbourne, Australia.

Jana Metta (J)

Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia; Centre for Advanced Histology and Microscopy, Peter MacCallum Cancer Centre, Melbourne, Australia.

Annette M Lim (AM)

The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.

Benjamin J Solomon (BJ)

Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.

Danny Rischin (D)

The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia. Electronic address: danny.rischin@petermac.org.

Classifications MeSH