Updating the study protocol: Insight 46 - a longitudinal neuroscience sub-study of the MRC National Survey of Health and Development - phases 2 and 3.
Ageing
Alzheimer’s disease
Birth cohort
Cognition
Epidemiology
Genetics
Life course
Magnetic resonance imaging
Positron emission tomography
Vascular disease
Journal
BMC neurology
ISSN: 1471-2377
Titre abrégé: BMC Neurol
Pays: England
ID NLM: 100968555
Informations de publication
Date de publication:
23 Jan 2024
23 Jan 2024
Historique:
received:
30
08
2023
accepted:
13
11
2023
medline:
24
1
2024
pubmed:
24
1
2024
entrez:
23
1
2024
Statut:
epublish
Résumé
Although age is the biggest known risk factor for dementia, there remains uncertainty about other factors over the life course that contribute to a person's risk for cognitive decline later in life. Furthermore, the pathological processes leading to dementia are not fully understood. The main goals of Insight 46-a multi-phase longitudinal observational study-are to collect detailed cognitive, neurological, physical, cardiovascular, and sensory data; to combine those data with genetic and life-course information collected from the MRC National Survey of Health and Development (NSHD; 1946 British birth cohort); and thereby contribute to a better understanding of healthy ageing and dementia. Phase 1 of Insight 46 (2015-2018) involved the recruitment of 502 members of the NSHD (median age = 70.7 years; 49% female) and has been described in detail by Lane and Parker et al. 2017. The present paper describes phase 2 (2018-2021) and phase 3 (2021-ongoing). Of the 502 phase 1 study members who were invited to a phase 2 research visit, 413 were willing to return for a clinic visit in London and 29 participated in a remote research assessment due to COVID-19 restrictions. Phase 3 aims to recruit 250 study members who previously participated in both phases 1 and 2 of Insight 46 (providing a third data time point) and 500 additional members of the NSHD who have not previously participated in Insight 46. The NSHD is the oldest and longest continuously running British birth cohort. Members of the NSHD are now at a critical point in their lives for us to investigate successful ageing and key age-related brain morbidities. Data collected from Insight 46 have the potential to greatly contribute to and impact the field of healthy ageing and dementia by combining unique life course data with longitudinal multiparametric clinical, imaging, and biomarker measurements. Further protocol enhancements are planned, including in-home sleep measurements and the engagement of participants through remote online cognitive testing. Data collected are and will continue to be made available to the scientific community.
Sections du résumé
BACKGROUND
BACKGROUND
Although age is the biggest known risk factor for dementia, there remains uncertainty about other factors over the life course that contribute to a person's risk for cognitive decline later in life. Furthermore, the pathological processes leading to dementia are not fully understood. The main goals of Insight 46-a multi-phase longitudinal observational study-are to collect detailed cognitive, neurological, physical, cardiovascular, and sensory data; to combine those data with genetic and life-course information collected from the MRC National Survey of Health and Development (NSHD; 1946 British birth cohort); and thereby contribute to a better understanding of healthy ageing and dementia.
METHODS/DESIGN
METHODS
Phase 1 of Insight 46 (2015-2018) involved the recruitment of 502 members of the NSHD (median age = 70.7 years; 49% female) and has been described in detail by Lane and Parker et al. 2017. The present paper describes phase 2 (2018-2021) and phase 3 (2021-ongoing). Of the 502 phase 1 study members who were invited to a phase 2 research visit, 413 were willing to return for a clinic visit in London and 29 participated in a remote research assessment due to COVID-19 restrictions. Phase 3 aims to recruit 250 study members who previously participated in both phases 1 and 2 of Insight 46 (providing a third data time point) and 500 additional members of the NSHD who have not previously participated in Insight 46.
DISCUSSION
CONCLUSIONS
The NSHD is the oldest and longest continuously running British birth cohort. Members of the NSHD are now at a critical point in their lives for us to investigate successful ageing and key age-related brain morbidities. Data collected from Insight 46 have the potential to greatly contribute to and impact the field of healthy ageing and dementia by combining unique life course data with longitudinal multiparametric clinical, imaging, and biomarker measurements. Further protocol enhancements are planned, including in-home sleep measurements and the engagement of participants through remote online cognitive testing. Data collected are and will continue to be made available to the scientific community.
Identifiants
pubmed: 38263061
doi: 10.1186/s12883-023-03465-3
pii: 10.1186/s12883-023-03465-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
40Subventions
Organisme : Alzheimer's Association
ID : SG-666374-UK BIRTH COHORT PI Schott
Pays : United States
Organisme : Alzheimer's Association
ID : SG-666374-UK BIRTH COHORT PI Schott
Pays : United States
Organisme : Alzheimer's Association
ID : SG-666374-UK BIRTH COHORT PI Schott
Pays : United States
Organisme : Alzheimer's Association
ID : SG-666374-UK BIRTH COHORT PI Schott
Pays : United States
Organisme : Alzheimer's Association
ID : SG-666374-UK BIRTH COHORT PI Schott
Pays : United States
Organisme : Alzheimer's Association
ID : SG-666374-UK BIRTH COHORT PI Schott
Pays : United States
Organisme : Alzheimer's Association
ID : SG-666374-UK BIRTH COHORT PI Schott
Pays : United States
Organisme : Alzheimer's Association
ID : SG-666374-UK BIRTH COHORT PI Schott
Pays : United States
Organisme : Alzheimer's Association
ID : SG-666374-UK BIRTH COHORT PI Schott
Pays : United States
Organisme : Alzheimer's Association
ID : SG-666374-UK BIRTH COHORT PI Schott
Pays : United States
Organisme : Alzheimer's Association
ID : SG-666374-UK BIRTH COHORT PI Schott
Pays : United States
Organisme : Alzheimer's Association
ID : SG-666374-UK BIRTH COHORT PI Schott
Pays : United States
Organisme : Alzheimer's Association
ID : SG-666374-UK BIRTH COHORT PI Schott
Pays : United States
Organisme : Alzheimer's Association
ID : SG-666374-UK BIRTH COHORT PI Schott
Pays : United States
Informations de copyright
© 2024. The Author(s).
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