Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity.


Journal

Bone research
ISSN: 2095-4700
Titre abrégé: Bone Res
Pays: China
ID NLM: 101608652

Informations de publication

Date de publication:
24 Jan 2024
Historique:
received: 05 07 2023
accepted: 15 12 2023
revised: 08 11 2023
medline: 24 1 2024
pubmed: 24 1 2024
entrez: 23 1 2024
Statut: epublish

Résumé

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis, which is characterized by increased bone resorption and inadequate bone formation. As novel antiosteoporotic therapeutics are needed, understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment targets. This study aimed to provide an overview of transcriptional reprogramming during human osteoclast differentiation. Osteoclasts were differentiated from CD14

Identifiants

pubmed: 38263167
doi: 10.1038/s41413-023-00312-6
pii: 10.1038/s41413-023-00312-6
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

5

Subventions

Organisme : Lundbeckfonden (Lundbeck Foundation)
ID : R335-2019-2195
Organisme : Lundbeckfonden (Lundbeck Foundation)
ID : R335-2019-2195
Organisme : Novo Nordisk Fonden (Novo Nordisk Foundation)
ID : NNF18OC0052699
Organisme : Novo Nordisk Fonden (Novo Nordisk Foundation)
ID : NNF18OC0055047
Organisme : Wellcome Trust (Wellcome)
ID : SBF004|1034
Organisme : Wellcome Trust (Wellcome)
ID : 224155/Z/21/Z
Organisme : Odense Universitetshospital (Odense University Hospital)
ID : A3147

Informations de copyright

© 2024. The Author(s).

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Auteurs

Morten S Hansen (MS)

Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital, DK-5000, Odense C, Denmark.
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, DK-5000, Odense C, Denmark.
Clinical Cell Biology, Pathology Research Unit, Department of Clinical Research, University of Southern Denmark, DK-5000, Odense C, Denmark.

Kaja Madsen (K)

Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital, DK-5000, Odense C, Denmark.
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, DK-5000, Odense C, Denmark.

Maria Price (M)

Institute of Metabolism and Systems Research (IMSR) and Centre for Diabetes, Endocrinology and Metabolism (CEDAM), University of Birmingham, Birmingham, B15 2TT, UK.
Centre for Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, B15 2TT, UK.

Kent Søe (K)

Clinical Cell Biology, Pathology Research Unit, Department of Clinical Research, University of Southern Denmark, DK-5000, Odense C, Denmark.
Department of Molecular Medicine, University of Southern Denmark, DK-5000, Odense C, Denmark.

Yasunori Omata (Y)

Department of Orthopedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, D-91054, Erlangen, Germany.

Mario M Zaiss (MM)

Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, D-91054, Erlangen, Germany.
Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, D-91054, Erlangen, Germany.

Caroline M Gorvin (CM)

Institute of Metabolism and Systems Research (IMSR) and Centre for Diabetes, Endocrinology and Metabolism (CEDAM), University of Birmingham, Birmingham, B15 2TT, UK.
Centre for Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, B15 2TT, UK.

Morten Frost (M)

Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital, DK-5000, Odense C, Denmark. mmfnielsen@health.sdu.dk.
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, DK-5000, Odense C, Denmark. mmfnielsen@health.sdu.dk.
Steno Diabetes Center Odense, Odense University Hospital, DK-5000, Odense C, Denmark. mmfnielsen@health.sdu.dk.

Alexander Rauch (A)

Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital, DK-5000, Odense C, Denmark. arauch@health.sdu.dk.
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, DK-5000, Odense C, Denmark. arauch@health.sdu.dk.
Steno Diabetes Center Odense, Odense University Hospital, DK-5000, Odense C, Denmark. arauch@health.sdu.dk.

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