Platelet-Derived Growth Factor Nanocapsules with Tunable Controlled Release for Chronic Wound Healing.
chronic wound healing
controlled release
nanocapsule
platelet-derived growth factor
protein delivery
Journal
Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338
Informations de publication
Date de publication:
23 Jan 2024
23 Jan 2024
Historique:
revised:
11
01
2024
received:
21
11
2023
medline:
24
1
2024
pubmed:
24
1
2024
entrez:
24
1
2024
Statut:
aheadofprint
Résumé
Chronic wounds have emerged as an increasingly critical clinical challenge over the past few decades, due to their increasing incidence and socioeconomic burdens. Platelet-derived growth factor (PDGF) plays a pivotal role in regulating processes such as fibroblast migration, proliferation, and vascular formation during the wound healing process. The delivery of PDGF offers great potential for expediting the healing of chronic wounds. However, the clinical effectiveness of PDGF in chronic wound healing is significantly hampered by its inability to maintain a stable concentration at the wound site over an extended period. In this study, a controlled PDGF delivery system based on nanocapsules is proposed. In this system, PDGF is encapsulated within a degradable polymer shell. The release rate of PDGF from these nanocapsules can be precisely adjusted by controlling the ratios of two crosslinkers with different degradation rates within the shells. As demonstrated in a diabetic wound model, improved therapeutic outcomes with PDGF nanocapsules (nPDGF) treatment are observed. This research introduces a novel PDGF delivery platform that holds promise for enhancing the effectiveness of chronic wound healing.
Identifiants
pubmed: 38263812
doi: 10.1002/smll.202310743
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2310743Subventions
Organisme : National Key Research and Development Program of China
ID : 2021YFC2102800
Organisme : National Natural Science Foundation of China
ID : 82173787
Organisme : Beijing Natural Science Foundation-Changping Innovation Joint Fund
ID : L234016
Informations de copyright
© 2024 Wiley-VCH GmbH.
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