The impact of a tDCS and cognitive training intervention on task-based functional connectivity.
Cognitive training
Functional connectivity
Transcranial direct current stimulation
UFOV
tDCS
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
24 Jan 2024
24 Jan 2024
Historique:
received:
24
08
2023
accepted:
15
01
2024
medline:
24
1
2024
pubmed:
24
1
2024
entrez:
24
1
2024
Statut:
aheadofprint
Résumé
Declines in several cognitive domains, most notably processing speed, occur in non-pathological aging. Given the exponential growth of the older adult population, declines in cognition serve as a significant public health issue that must be addressed. Promising studies have shown that cognitive training in older adults, particularly using the useful field of view (UFOV) paradigm, can improve cognition with moderate to large effect sizes. Additionally, meta-analyses have found that transcranial direct current stimulation (tDCS), a non-invasive form of brain stimulation, can improve cognition in attention/processing speed and working memory. However, only a handful of studies have looked at concomitant tDCS and cognitive training, usually with short interventions and small sample sizes. The current study assessed the effect of a tDCS (active versus sham) and a 3-month cognitive training intervention on task-based functional connectivity during completion of the UFOV task in a large older adult sample (N = 153). We found significant increased functional connectivity between the left and right pars triangularis (the ROIs closest to the electrodes) following active, but not sham tDCS. Additionally, we see trending behavioral improvements associated with these functional connectivity changes in the active tDCS group, but not sham. Collectively, these findings suggest that tDCS and cognitive training can be an effective modulator of task-based functional connectivity above and beyond a cognitive training intervention alone.
Identifiants
pubmed: 38265579
doi: 10.1007/s11357-024-01077-4
pii: 10.1007/s11357-024-01077-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : R01AG054077
Pays : United States
Organisme : NIA NIH HHS
ID : P30AG019610
Pays : United States
Organisme : NIA NIH HHS
ID : T32AG020499
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32HL134621
Pays : United States
Informations de copyright
© 2024. The Author(s), under exclusive licence to American Aging Association.
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