The involvement of the human prefrontal cortex in the emergence of visual awareness.
event related potential
frontal lobe
human
iEEG
local field potential
neuroscience
saccade
visual consciousness
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
24 Jan 2024
24 Jan 2024
Historique:
medline:
25
1
2024
pubmed:
24
1
2024
entrez:
24
1
2024
Statut:
epublish
Résumé
Exploring the neural mechanisms of awareness is a fundamental task of cognitive neuroscience. There is an ongoing dispute regarding the role of the prefrontal cortex (PFC) in the emergence of awareness, which is partially raised by the confound between report- and awareness-related activity. To address this problem, we designed a visual awareness task that can minimize report-related motor confounding. Our results show that saccadic latency is significantly shorter in the aware trials than in the unaware trials. Local field potential (LFP) data from six patients consistently show early (200-300ms) awareness-related activity in the PFC, including event-related potential and high-gamma activity. Moreover, the awareness state can be reliably decoded by the neural activity in the PFC since the early stage, and the neural pattern is dynamically changed rather than being stable during the representation of awareness. Furthermore, the enhancement of dynamic functional connectivity, through the phase modulation at low frequency, between the PFC and other brain regions in the early stage of the awareness trials may explain the mechanism of conscious access. These results indicate that the PFC is critically involved in the emergence of awareness.
Identifiants
pubmed: 38265851
doi: 10.7554/eLife.89076
pii: 89076
doi:
pii:
Banques de données
Dryad
['10.5061/dryad.p8cz8w9xp']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science and Technology of the People's Republic of China
ID : STI2030-Major Projects+2021ZD0204300
Organisme : National Natural Science Foundation of China
ID : 32061143004
Organisme : National Natural Science Foundation of China
ID : 32030045
Organisme : State Key Laboratory of Cognitive Neuroscience and Learning
ID : Open Research Fund CNLZD2202
Informations de copyright
© 2023, Fang et al.
Déclaration de conflit d'intérêts
ZF, YD, ZL, YH, HZ, XX, MZ No competing interests declared
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