CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice.

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
26 Jan 2024
Historique:
medline: 24 1 2024
pubmed: 24 1 2024
entrez: 24 1 2024
Statut: ppublish

Résumé

The brain-specific enzyme CYP46A1 controls cholesterol turnover by converting cholesterol into 24

Identifiants

DOI: 10.1126/sciadv.adj1354 PMID: 38266095
pubmed: 38266095
doi: 10.1126/sciadv.adj1354
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadj1354

Auteurs

María Latorre-Leal (M)

Department of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-8434-3822

Patricia Rodriguez-Rodriguez (P)

Department of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-2438-3515

Luca Franchini (L)

Department of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.

Orestis Nikolidakis (O)

Department of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0009-0006-2685-8736

Makrina Daniilidou (M)

Department of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
Department of Neurobiology Care Sciences and Society, Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.

Ljerka Delac (L)

Department of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0003-1840-1710

Mukesh K Varshney (MK)

Department of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
ORCID: 0000-0003-2165-0152

Luis E Arroyo-García (LE)

Department of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-9206-0179

Francesca Eroli (F)

Department of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.

Bengt Winblad (B)

Department of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-0011-1179

Kaj Blennow (K)

Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Institut du Cerveau et de la Moelle épinière (ICM), Pitié-Salpêtrière Hospital, Sorbonne Université, Paris, France.
University of Science and Technology of China, Hefei, Anhui, P.R. China.
ORCID: 0000-0002-1890-4193

Henrik Zetterberg (H)

Institute of Neuroscience and Physiology, University of Gothenburg, Mölndal, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
ORCID: 0000-0003-3930-4354

Miia Kivipelto (M)

Department of Neurobiology Care Sciences and Society, Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
Theme Aging, Karolinska University Hospital, Stockholm, Sweden.
ORCID: 0000-0003-0992-3875

Manuela Pacciarini (M)

Swansea University Medical School, SA2 8PP Swansea, UK.

Yuqin Wang (Y)

Swansea University Medical School, SA2 8PP Swansea, UK.
ORCID: 0000-0002-3063-3066

William J Griffiths (WJ)

Swansea University Medical School, SA2 8PP Swansea, UK.
ORCID: 0000-0002-4129-6616

Ingemar Björkhem (I)

Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden.

Anna Matton (A)

Department of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
Department of Neurobiology Care Sciences and Society, Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-7819-0495

Ivan Nalvarte (I)

Department of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
ORCID: 0000-0001-6828-2583

Paula Merino-Serrais (P)

Department of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
Departamento de Neurobiología Funcional y de Sistemas, Instituto Cajal, CSIC, Madrid, Spain.
Laboratorio Cajal de Circuitos Corticales, Centro de Tecnología Biomédica, UPM, Madrid, Spain.
ORCID: 0000-0002-1842-9476

Angel Cedazo-Minguez (A)

Department of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0003-4626-4864

Silvia Maioli (S)

Department of Neurobiology Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-9577-0803

Classifications MeSH