Myosin light chain 6 (Myl6) interacts with kindlin-3 and is required to support integrin αIIbβ3 activation in platelets in mice.
Integrin αIIbβ3
Kindlin-3
Myl6
Platelets
Journal
Journal of thrombosis and haemostasis : JTH
ISSN: 1538-7836
Titre abrégé: J Thromb Haemost
Pays: England
ID NLM: 101170508
Informations de publication
Date de publication:
22 Jan 2024
22 Jan 2024
Historique:
received:
07
08
2023
revised:
03
01
2024
accepted:
08
01
2024
medline:
25
1
2024
pubmed:
25
1
2024
entrez:
24
1
2024
Statut:
aheadofprint
Résumé
Kindlin-3 in platelets plays an essential role in supporting integrin αIIbβ3 activation, platelet spreading, aggregation, and clot retraction by binding to the integrin β3 cytoplasmic tail. However, the mechanism by which kindlin-3 mediates the crosstalk between integrin αIIbβ3 and myosin in platelets remains unknown. To examine the role of Myl6 in supporting integrin αIIbβ3 activation in platelets. Myl6 We identified a novel kindlin-3 binding protein, Myl6, an essential light chain of myosin in platelets. Myl6 In summary, these results suggest that Myl6, as a novel kindlin-3 binding partner, is required to support integrin αIIbβ3 activation in platelets, playing an important role in both hemostasis and thrombosis.
Sections du résumé
BACKGROUND
BACKGROUND
Kindlin-3 in platelets plays an essential role in supporting integrin αIIbβ3 activation, platelet spreading, aggregation, and clot retraction by binding to the integrin β3 cytoplasmic tail. However, the mechanism by which kindlin-3 mediates the crosstalk between integrin αIIbβ3 and myosin in platelets remains unknown.
OBJECTIVES
OBJECTIVE
To examine the role of Myl6 in supporting integrin αIIbβ3 activation in platelets.
METHODS
METHODS
Myl6
RESULTS
RESULTS
We identified a novel kindlin-3 binding protein, Myl6, an essential light chain of myosin in platelets. Myl6
CONCLUSIONS
CONCLUSIONS
In summary, these results suggest that Myl6, as a novel kindlin-3 binding partner, is required to support integrin αIIbβ3 activation in platelets, playing an important role in both hemostasis and thrombosis.
Identifiants
pubmed: 38266679
pii: S1538-7836(24)00044-8
doi: 10.1016/j.jtha.2024.01.007
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 International Society on Thrombosis and Haemostasis. Published by Elsevier Inc. All rights reserved.