Selective Bowman's layer transplantation in the treatment of neurotrophic corneal ulcers.
Journal
Indian journal of ophthalmology
ISSN: 1998-3689
Titre abrégé: Indian J Ophthalmol
Pays: India
ID NLM: 0405376
Informations de publication
Date de publication:
01 Feb 2024
01 Feb 2024
Historique:
received:
26
05
2023
accepted:
12
07
2023
medline:
25
1
2024
pubmed:
25
1
2024
entrez:
25
1
2024
Statut:
ppublish
Résumé
The aim of this paper is to present the surgical technique of selective Bowman's layer transplantation as well as the results of the surgery in patients with trophic corneal ulcers. The methodology of the study included three eyes from three patients with neurotrophic corneal ulcers grafting with corneal Bowman's layer. Pre- and postoperative analyses of the anterior segment of the eye were based on optical coherence tomography and slit-lamp assessment. Postoperatively a gradual corneal stroma restoration and fast corneal epithelialization were noticed. Based on our observations, the stiff and firm structure of Bowman's layer is supposed to strengthen the corneal surface and maintain its shape. It acts also as an antipathogen and antitoxin corneal barrier. Application of this acellular corneal layer transplantation to cover trophic corneal ulcers is an interesting, modern and crucial method of neurotrophic keratitis treatment.
Identifiants
pubmed: 38271428
doi: 10.4103/IJO.IJO_1371_23
pii: 02223307-202472002-00025
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
S308-S311Informations de copyright
Copyright © 2024 Copyright: © 2024 Indian Journal of Ophthalmology.
Références
Mackie IA. Neuroparalytic keratitis Fraunfelder F, Roy FH, Meyer SM. Current Ocular Therapy. Philadelphia, PA, USA: WB Saunders; 1995. 452–4.
Bonini S, Lambiase A, Rama P, Caprioglio G, Aloe L. Topical treatment with nerve growth factor for neurotrophic keratitis. Ophthalmology 2000;107:1347–51.
Hsu HY, Modi D. Etiologies, quantitative hypoesthesia, and clinical outcomes of neurotrophic keratopathy. Eye Contact Lens 2015;41:314–7.
Sacchetti M, Lambiase A. Diagnosis and management of neurotrophic keratitis. Clin Ophthalmol 2014;8:571–9.
Wilson SE, Hong JW. Bowman's layer structure and function:Critical or dispensable to corneal function?A hypothesis. Cornea 2000;19:417–20.
Patel S, Reinstein DZ, Silverman RH, Coleman DJ. The shape of Bowman's layer in the human cornea. J Refract Surg 1998;14:636–40.
Mantelli F, Mauris J, Argüeso P. The ocular surface epithelial barrier and other mechanisms of mucosal protection:From allergy to infectious diseases. Curr Opin Allergy Clin Immunol 2013;13:563–8.
Klyce SD, Beuerman RW. Structure and function of the cornea Kaufman HE, Barron BA, McDonald MB, Waltman SR. The Cornea. New York: Churchill Livingstone; 1988. 3–54.
Lagali N, Germundsson J, Fagerholm P. The role of Bowman's layer in corneal regeneration after phototherapeutic keratectomy:A prospective study using in vivo confocal microscopy. Invest Ophthalmol Vis Sc 2009;50:41928.