Genetic and Epigenetic Profiles of Polycystic Ovarian Syndrome and In Vitro Bisphenol Exposure in a Human Granulosa Cell Model.

bisphenols endocrine disrupting compounds granulosa cells microRNAs polycystic ovary syndrome

Journal

Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304

Informations de publication

Date de publication:
21 Jan 2024
Historique:
received: 21 12 2023
revised: 14 01 2024
accepted: 19 01 2024
medline: 26 1 2024
pubmed: 26 1 2024
entrez: 26 1 2024
Statut: epublish

Résumé

Higher levels of bisphenols are found in granulosa cells of women with polycystic ovary syndrome (PCOS), posing the question: Is bisphenol exposure linked to PCOS pathophysiology? Human granulosa cells were obtained from women with and without PCOS, and genes and microRNAs associated with PCOS were investigated. The first phase compared healthy women and those with PCOS, revealing distinct patterns: PCOS subjects had lower

Identifiants

DOI: 10.3390/biomedicines12010237 PMID: 38275408
pubmed: 38275408
pii: biomedicines12010237
doi: 10.3390/biomedicines12010237
pii:
doi:

Types de publication

Journal Article

Langues

eng

Auteurs

Reem Sabry (R)

Reproductive Health and Biotechnology Laboratory, Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.
ORCID: 0000-0002-5558-3114

Jenna F Gallo (JF)

Reproductive Health and Biotechnology Laboratory, Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.
ONE Fertility, Burlington, ON L7N 3T1, Canada.

Charlie Rooney (C)

Reproductive Health and Biotechnology Laboratory, Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.

Olivia L M Scandlan (OLM)

Reproductive Health and Biotechnology Laboratory, Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.

Ola S Davis (OS)

Reproductive Health and Biotechnology Laboratory, Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.

Shilpa Amin (S)

ONE Fertility, Burlington, ON L7N 3T1, Canada.
Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON L8S 4L8, Canada.

Mehrnoosh Faghih (M)

ONE Fertility, Burlington, ON L7N 3T1, Canada.
Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON L8S 4L8, Canada.

Megan Karnis (M)

ONE Fertility, Burlington, ON L7N 3T1, Canada.
Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON L8S 4L8, Canada.

Michael S Neal (MS)

ONE Fertility, Burlington, ON L7N 3T1, Canada.
Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON L8S 4L8, Canada.
ORCID: 0000-0002-4670-018X

Laura A Favetta (LA)

Reproductive Health and Biotechnology Laboratory, Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.
ORCID: 0000-0001-5757-568X

Classifications MeSH