Trihexyphenidyl Alters Its Host's Metabolism, Neurobehavioral Patterns, and Gut Microbiome Feedback Loop-The Modulating Role of

Anacyclus pyrethrum addiction dependence drug dependence gut–brain axis microbiome oxidative stress pellitory substance abuse trihexyphenidyl (Artane)

Journal

Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981

Informations de publication

Date de publication:
21 Dec 2023
Historique:
received: 02 11 2023
revised: 11 12 2023
accepted: 19 12 2023
medline: 26 1 2024
pubmed: 26 1 2024
entrez: 26 1 2024
Statut: epublish

Résumé

Trihexyphenidyl (THP)-a synthetic anticholinergic medication used to manage parkinsonism and extrapyramidal symptoms-has gained significant clinical recognition. However, there is a critical gap in understanding its withdrawal effects. This study investigates the intricate interplay between gut microbiota and oxidative stress during THP withdrawal. Furthermore, it explores the therapeutic potential of

Identifiants

DOI: 10.3390/antiox13010026 PMID: 38275646
pubmed: 38275646
pii: antiox13010026
doi: 10.3390/antiox13010026
pii:
doi:

Types de publication

Journal Article

Langues

eng

Auteurs

Abdelmounaim Baslam (A)

Laboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Department of Biology, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech 40000, Morocco.
ORCID: 0000-0001-9320-3613

Hajar Azraida (H)

Laboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Department of Biology, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech 40000, Morocco.
ORCID: 0000-0002-2208-8264

Rachida Aboufatima (R)

Laboratory of Biological Engineering, Faculty of Sciences and Technology, Sultan Moulay Slimane University, Beni Mellal 23000, Morocco.

Mohamed Ait-El-Mokhtar (M)

Laboratory of Biochemistry, Environment & Agri-Food URAC 36, Department of Biology, Faculty of Science and Techniques-Mohammedia, Hassan II University of Casablanca, Mohammedia 20000, Morocco.
ORCID: 0000-0001-8096-9927

Ilham Dilagui (I)

Laboratory of Microbiology, University Hospital Mohamed VI, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech 40000, Morocco.

Samia Boussaa (S)

Higher Institute of Nursing and Health Techniques, Ministry of Health and Social Protection, Rabat 10000, Morocco.
ORCID: 0000-0002-5599-1097

Abderrahman Chait (A)

Laboratory of Pharmacology, Neurobiology, Anthropobiology and Environment, Department of Biology, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech 40000, Morocco.
ORCID: 0000-0002-5639-1931

Marouane Baslam (M)

Laboratory of Biochemistry, Department of Applied Biological Chemistry, Faculty of Agriculture, University of Niigata, Niigata 950-2181, Japan.
Center of Agrobiotechnology and Bioengineering, Research Unit Labelled CNRST (Centre AgroBiotech-URL-7 CNRST-05), Cadi Ayyad University, Marrakech 40000, Morocco.
Laboratory of Agro-Food, Biotechnologies and Valorization of Plant Bioresources (AGROBIOVAL), Department of Biology, Faculty of Science Semlalia, Cadi Ayyad University (UCA), Marrakech 40000, Morocco.
ORCID: 0000-0003-3598-7565

Classifications MeSH