MEndoB, a chimeric lysin featuring a novel domain architecture and superior activity for the treatment of staphylococcal infections.

MRSA Staphylococcus aureus antibiotic resistance antibiotics bacteremia bacteriophage endolysin peptidoglycan hydrolase protein therapeutics staphylococci

Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
26 Jan 2024
Historique:
medline: 26 1 2024
pubmed: 26 1 2024
entrez: 26 1 2024
Statut: aheadofprint

Résumé

Bacterial infections are a growing global healthcare concern, as an estimated annual 4.95 million deaths are associated with antimicrobial resistance (AMR). Methicillin-resistant

Identifiants

pubmed: 38275913
doi: 10.1128/mbio.02540-23
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0254023

Auteurs

Christian Roehrig (C)

Micreos Pharmaceuticals AG, Baar, Zug, Switzerland.
Micreos GmbH, Wädenswil, Zurich, Switzerland.

Markus Huemer (M)

Micreos GmbH, Wädenswil, Zurich, Switzerland.

Dominique Lorgé (D)

Micreos GmbH, Wädenswil, Zurich, Switzerland.

Fabienne Arn (F)

Micreos GmbH, Wädenswil, Zurich, Switzerland.

Nadine Heinrich (N)

Micreos GmbH, Wädenswil, Zurich, Switzerland.

Lavanja Selvakumar (L)

Micreos GmbH, Wädenswil, Zurich, Switzerland.

Lynn Gasser (L)

Institute of Chemistry and Biotechnology, Zurich University of Applied Sciences (ZHAW), Wädenswil, Zurich, Switzerland.

Patrick Hauswirth (P)

Institute of Chemistry and Biotechnology, Zurich University of Applied Sciences (ZHAW), Wädenswil, Zurich, Switzerland.

Chun-Chi Chang (C-C)

Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Tiziano A Schweizer (TA)

Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Fritz Eichenseher (F)

Micreos GmbH, Wädenswil, Zurich, Switzerland.

Steffi Lehmann (S)

Institute of Chemistry and Biotechnology, Zurich University of Applied Sciences (ZHAW), Wädenswil, Zurich, Switzerland.

Annelies S Zinkernagel (AS)

Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Mathias Schmelcher (M)

Micreos GmbH, Wädenswil, Zurich, Switzerland.

Classifications MeSH