A fluorescent probe for selective detection of lysosomal β-hexosaminidase in live cells.

Coumarin Fluorescent probe Live cell imaging Rhodol β-hexosaminidase

Journal

Talanta
ISSN: 1873-3573
Titre abrégé: Talanta
Pays: Netherlands
ID NLM: 2984816R

Informations de publication

Date de publication:
23 Jan 2024
Historique:
received: 28 11 2023
revised: 19 01 2024
accepted: 22 01 2024
medline: 28 1 2024
pubmed: 28 1 2024
entrez: 27 1 2024
Statut: aheadofprint

Résumé

Determining the activity of lysosomal β-hexosaminidase in cells is of great importance for understanding the roles that these enzymes play in pathophysiological events. Herein, we designed the new fluorescent probe, βGalNAc-Rhod-CM(NEt

Identifiants

pubmed: 38280264
pii: S0039-9140(24)00094-8
doi: 10.1016/j.talanta.2024.125715
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

125715

Informations de copyright

Copyright © 2024 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Injae Shin reports financial support was provided by National Research Foundation of Korea. Sung-Kyun Ko reports financial support was provided by Korea Research Institute of Bioscience and Biotechnology. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Jongwon Lee (J)

Department of Chemistry, Yonsei University, Seoul, 03722, Republic of Korea.

Jihyeon Boo (J)

Department of Chemistry, Yonsei University, Seoul, 03722, Republic of Korea.

Young-Hyun Kim (YH)

Department of Chemistry, Yonsei University, Seoul, 03722, Republic of Korea.

Jongtae Roh (J)

Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, 28116, Republic of Korea; Department of Bio-Molecular Science, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, 34141, Republic of Korea.

Sung-Kyun Ko (SK)

Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, 28116, Republic of Korea; Department of Bio-Molecular Science, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, 34141, Republic of Korea.

Injae Shin (I)

Department of Chemistry, Yonsei University, Seoul, 03722, Republic of Korea. Electronic address: injae@yonsei.ac.kr.

Classifications MeSH