Eudesmane sesquiterpenoids with inhibitory effects on NO production from Artemisia princeps.

Artemisia / chemistry Molecular Structure Sesquiterpenes / chemistry Structure-Activity Relationship Sesquiterpenes, Eudesmane / pharmacology
Anti-inflammation Artemisia princeps Pamp. Asteraceae Eudesmane sesquiterpenoid

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
Apr 2024
Historique:
received: 11 11 2023
revised: 18 01 2024
accepted: 21 01 2024
medline: 18 3 2024
pubmed: 29 1 2024
entrez: 28 1 2024
Statut: ppublish

Résumé

Five undescribed eudesmane methyl esters (1-5), three undescribed eudesmane-12,6-olides (6-8), and 21 known analogues (9-29) were isolated from the aerial part of Artemisia princeps Pamp. Their structures were established by detailed analysis of the NMR and HRESIMS data. The absolute configurations of 1-8 were determined based on single-crystal X-ray diffraction analysis and ECD calculations. Moreover, the inhibitory effects on LPS-induced NO production in BV-2 microglial cells of all the isolated compounds were assessed. Except for compounds 2, 4, 10, and 11, the others showed significant inhibitory activities, with IC

Identifiants

DOI: 10.1016/j.phytochem.2024.113999 PMID: 38281703
pubmed: 38281703
pii: S0031-9422(24)00036-0
doi: 10.1016/j.phytochem.2024.113999
pii:
doi:

Substances chimiques

Sesquiterpenes 0
eudesmane 473-11-0
Sesquiterpenes, Eudesmane 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113999

Informations de copyright

Copyright © 2024 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Hong-Xia Li (HX)

Guangxi Key Laboratory of Drug Discovery and Optimization, Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, Key Laboratory of Medical Biotechnology and Translational Medicine, School of Pharmacy, Guilin Medical University, Guilin 541199, Guangxi, People's Republic of China.

Ning Diao (N)

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.

Ya-Jie Hu (YJ)

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.

Su-Juan Wang (SJ)

Guangxi Key Laboratory of Drug Discovery and Optimization, Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, Key Laboratory of Medical Biotechnology and Translational Medicine, School of Pharmacy, Guilin Medical University, Guilin 541199, Guangxi, People's Republic of China.

Dong Liang (D)

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China. Electronic address: liangdonggxnu@163.com.

Gui-Jie Zhang (GJ)

Guangxi Key Laboratory of Drug Discovery and Optimization, Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, Key Laboratory of Medical Biotechnology and Translational Medicine, School of Pharmacy, Guilin Medical University, Guilin 541199, Guangxi, People's Republic of China. Electronic address: zhangguijie001@126.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Asteraceae › Artemisia › Eudesmane sesquiterpenoids with inhibitory...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Eudesmane sesquiterpenoids with inhibitory...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › Eudesmane sesquiterpenoids with inhibitory...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Eudesmane sesquiterpenoids with inhibitory...
questionsmedicales.fr › Composés polycycliques › Sesquiterpènes polycycliques › Sesquiterpènes de type eudesmane › Eudesmane sesquiterpenoids with inhibitory...