Small organic molecules containing amorphous calcium phosphate: synthesis, characterization and transformation.

amorphous calcium phosphate ascorbate biomaterials biomimetics bone tissue engineering glutamate itaconate organic compounds

Journal

Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513

Informations de publication

Date de publication:
2023
Historique:
received: 29 10 2023
accepted: 13 12 2023
medline: 29 1 2024
pubmed: 29 1 2024
entrez: 29 1 2024
Statut: epublish

Résumé

As the primary solid phase, amorphous calcium phosphate (ACP) is a pivotal precursor in cellular biomineralization. The intrinsic interplay between ACP and Howard factor underscores the significance of understanding their association for advancing biomimetic ACP development. While organic compounds play established roles in biomineralization, this study presents the synthesis of ACP with naturally occurring organic compounds (ascorbate, glutamate, and itaconate) ubiquitously found in mitochondria and vital for bone remodeling and healing. The developed ACP with organic compounds was meticulously characterized using XRD, FTIR, and solid-state

Identifiants

DOI: 10.3389/fbioe.2023.1329752 PMID: 38283170 PMC: PMC10811600
pubmed: 38283170
doi: 10.3389/fbioe.2023.1329752
pii: 1329752
pmc: PMC10811600
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1329752

Informations de copyright

Copyright © 2024 Indurkar, Kudale, Rjabovs, Heinmaa, Demir, Kirejevs, Rubenis, Chaturbhuj, Turks and Locs.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Abhishek Indurkar (A)

Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Riga, Latvia.
Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Riga, Latvia.

Pawan Kudale (P)

Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India.

Vitālijs Rjabovs (V)

Institute of Technology of Organic Chemistry, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Riga, Latvia.

Ivo Heinmaa (I)

National Institute of Chemical Physics and Biophysics, Tallinn, Estonia.

Öznur Demir (Ö)

Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Riga, Latvia.
Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Riga, Latvia.

Matvejs Kirejevs (M)

Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Riga, Latvia.

Kristaps Rubenis (K)

Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Riga, Latvia.
Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Riga, Latvia.

Ganesh Chaturbhuj (G)

Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India.

Māris Turks (M)

Institute of Technology of Organic Chemistry, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Riga, Latvia.

Janis Locs (J)

Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Riga, Latvia.
Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, Riga, Latvia.

Classifications MeSH