Short- and Long-Term Effects on Glucose Control of Nonadherence to Insulin Therapy in People With Type 2 Diabetes An
computer simulation
diabetes complications
diabetes control
modeling
Journal
Journal of diabetes science and technology
ISSN: 1932-2968
Titre abrégé: J Diabetes Sci Technol
Pays: United States
ID NLM: 101306166
Informations de publication
Date de publication:
29 Jan 2024
29 Jan 2024
Historique:
medline:
29
1
2024
pubmed:
29
1
2024
entrez:
29
1
2024
Statut:
aheadofprint
Résumé
Strict adherence to multiple daily insulin (MDI) therapy is a cornerstone for the achievement of good glucose control in people with advanced type 2 diabetes (T2D). Here, we aim to We tuned the Padova T2D Simulator, originally describing early-stage T2D physiology, around advanced T2D people. One hundred A statistically significant degradation was found in all glucose control outcome metrics in Impaired adherence to MDI therapy in T2D leads to glucose control deteriorations in both short and long terms. Interestingly, short-term hyperglycemia seems being contrasted by residual endogenous insulin secretion, which statistically increased by 3-fold after delayed/skipped insulin boluses compared with optimal ones.
Sections du résumé
BACKGROUND
UNASSIGNED
Strict adherence to multiple daily insulin (MDI) therapy is a cornerstone for the achievement of good glucose control in people with advanced type 2 diabetes (T2D). Here, we aim to
METHODS
UNASSIGNED
We tuned the Padova T2D Simulator, originally describing early-stage T2D physiology, around advanced T2D people. One hundred
RESULTS
UNASSIGNED
A statistically significant degradation was found in all glucose control outcome metrics in
CONCLUSIONS
UNASSIGNED
Impaired adherence to MDI therapy in T2D leads to glucose control deteriorations in both short and long terms. Interestingly, short-term hyperglycemia seems being contrasted by residual endogenous insulin secretion, which statistically increased by 3-fold after delayed/skipped insulin boluses compared with optimal ones.
Identifiants
pubmed: 38284154
doi: 10.1177/19322968231223936
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
19322968231223936Déclaration de conflit d'intérêts
Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.