Swallowed topical corticosteroids for eosinophilic esophagitis: Utilization and real-world efficacy from the EoE CONNECT registry.

budesonide clinical remission dysphagia effectiveness eosinophil count eosinophilic esophagitis fluticasone propionate histological remission orodispersible swallowed topical corticosteroids

Journal

United European gastroenterology journal
ISSN: 2050-6414
Titre abrégé: United European Gastroenterol J
Pays: England
ID NLM: 101606807

Informations de publication

Date de publication:
29 Jan 2024
Historique:
received: 30 08 2023
accepted: 25 11 2023
medline: 29 1 2024
pubmed: 29 1 2024
entrez: 29 1 2024
Statut: aheadofprint

Résumé

Swallowed topical corticosteroids (tC) are common therapy for patients with eosinophilic esophagitis (EoE). Widely heterogeneous results have occurred due to their active ingredients, formulations and doses. To assess the effectiveness of topical corticosteroid therapy for EoE in real-world practice. Cross-sectional study analysis of the multicentre EoE CONNECT registry. Clinical remission was defined as a decrease of ≥50% in dysphagia symptom scores; histological remission was defined as a peak eosinophil count below 15 per high-power field. The effectiveness in achieving clinico-histological remission (CHR) was compared for the main tC formulations. Overall, data on 1456 prescriptions of tC in monotherapy used in 866 individual patients were assessed. Of those, 904 prescriptions with data on formulation were employed for the induction of remission; 234 reduced a previously effective dose for maintenance. Fluticasone propionate formulations dominated the first-line treatment, while budesonide was more common in later therapies. A swallowed nasal drop suspension was the most common formulation of fluticasone propionate. Doses ≥0.8 mg/day provided a 65% CHR rate and were superior to lower doses. Oral viscous solution prepared by a pharmacist was the most common prescription of budesonide; 4 mg/day provided no benefit over 2 mg/day (CHR rated being 72% and 80%, respectively). A multivariate analysis revealed budesonide orodispersible tablets as the most effective therapy (OR 18.9, p < 0.001); use of higher doses (OR 4.3, p = 0.03) and lower symptom scores (OR 0.9, p = 0.01) were also determinants of effectiveness. Reduced symptom severity, use of high doses, and use of budesonide orodispersible tablets particularly were all independent predictors of tC effectiveness.

Sections du résumé

BACKGROUND BACKGROUND
Swallowed topical corticosteroids (tC) are common therapy for patients with eosinophilic esophagitis (EoE). Widely heterogeneous results have occurred due to their active ingredients, formulations and doses.
OBJECTIVE OBJECTIVE
To assess the effectiveness of topical corticosteroid therapy for EoE in real-world practice.
METHODS METHODS
Cross-sectional study analysis of the multicentre EoE CONNECT registry. Clinical remission was defined as a decrease of ≥50% in dysphagia symptom scores; histological remission was defined as a peak eosinophil count below 15 per high-power field. The effectiveness in achieving clinico-histological remission (CHR) was compared for the main tC formulations.
RESULTS RESULTS
Overall, data on 1456 prescriptions of tC in monotherapy used in 866 individual patients were assessed. Of those, 904 prescriptions with data on formulation were employed for the induction of remission; 234 reduced a previously effective dose for maintenance. Fluticasone propionate formulations dominated the first-line treatment, while budesonide was more common in later therapies. A swallowed nasal drop suspension was the most common formulation of fluticasone propionate. Doses ≥0.8 mg/day provided a 65% CHR rate and were superior to lower doses. Oral viscous solution prepared by a pharmacist was the most common prescription of budesonide; 4 mg/day provided no benefit over 2 mg/day (CHR rated being 72% and 80%, respectively). A multivariate analysis revealed budesonide orodispersible tablets as the most effective therapy (OR 18.9, p < 0.001); use of higher doses (OR 4.3, p = 0.03) and lower symptom scores (OR 0.9, p = 0.01) were also determinants of effectiveness.
CONCLUSION CONCLUSIONS
Reduced symptom severity, use of high doses, and use of budesonide orodispersible tablets particularly were all independent predictors of tC effectiveness.

Identifiants

pubmed: 38284792
doi: 10.1002/ueg2.12533
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Instituto de Salud Carlos III
ID : JR19/00005

Informations de copyright

© 2024 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.

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Auteurs

Emilio J Laserna-Mendieta (EJ)

Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain.
Instituto de Investigación Sanitaria La Princesa, Madrid, Spain.
Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Madrid, Spain.
Laboratory Medicine Department, Hospital Universitario de La Princesa, Madrid, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain.

Pilar Navarro (P)

Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain.
Instituto de Investigación Sanitaria La Princesa, Madrid, Spain.
Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Madrid, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain.

Sergio Casabona-Francés (S)

Instituto de Investigación Sanitaria La Princesa, Madrid, Spain.
Department of Gastroenterology, Hospital Universitario de La Princesa, Madrid, Spain.

Edoardo V Savarino (EV)

Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
Gastroenterology Unit, Azienza Ospedaliera di Padova, Padova, Italy.

Edurne Amorena (E)

Department of Gastroenterology, Hospital Universitario de Navarra, Pamplona, Spain.

Isabel Pérez-Martínez (I)

Department of Gastroenterology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Diet, Microbiota and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.

Danila Guagnozzi (D)

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain.
Department of Gastroenterology, Hospital Universitario Valld'Hebrón, Barcelona, Spain.

Leonardo Blas-Jhon (L)

Department of Gastroenterology, Fundación Jiménez Díaz, Madrid, Spain.

Elena Betoré (E)

Department of Gastroenterology, Hospital Universitario Miguel Servet, Zaragoza, Spain.

Antonio Guardiola-Arévalo (A)

Department of Gastroenterology, Hospital Universitario de Fuenlabrada, Fuenlabrada, Spain.

Gaia Pellegatta (G)

Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Milan, Italy.
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

Anne Lund Krarup (AL)

Department of Emergency Medicine and Trauma Care, Aalborg University Hospital, Aalborg, Denmark.
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

Antonia Perello (A)

Department of Gastroenterology, Hospital de Viladecans, Viladecans, Spain.

Jesús Barrio (J)

Department of Gastroenterology, Hospital Universitario Rio Hortega, Valladolid, Spain.

Carolina Gutiérrez-Junquera (C)

Pediatric Gastroenterology Unit, Hospital Universitario Puerta de Hierro Majadahonda, Universidad Autónoma de Madrid, Madrid, Spain.

Carlos Teruel Sánchez-Vegazo (C)

Department of Gastroenterology, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Sonia Fernández-Fernández (S)

Department of Pediatric Gastroenterology, Hospital Universitario Severo Ochoa, Leganés, Spain.

Juan Enrique Naves (JE)

Department of Gastroenterology, Parc de Salut Mar, Barcelona, Spain.

Salvatore Oliva (S)

Pediatric Gastroenterology and Liver Unit, Maternal and Child Health Department, Sapienza - University of Rome, Rome, Italy.

Juan Armando Rodríguez-Oballe (JA)

Department of Gastroenterology, Hospital Universitario Arnau de Vilanova & Hospital Universitario Santa María, Lérida, Spain.

Silvia Carrión (S)

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain.
Department of Gastroenterology, Hospital de Mataró, Mataró, Spain.

Silvia Espina (S)

Department of Gastroenterology, Hospital General de la Defensa, Zaragoza, Spain.

Mónica Llorente Barrio (M)

Department of Gastroenterology, Hospital de Santa Bárbara, Soria, Spain.

Maria Lluisa Masiques-Mas (ML)

Department of Pediatric Gastroenterology, Hospital de Granollers, Granollers, Spain.

Raffaella Dainese (R)

Department of Gastroenterology, Centre Hospitalier d'Antibes Juan-les-Pins, Antibes, France.

Sara Feo-Ortega (S)

Instituto de Investigación Sanitaria La Princesa, Madrid, Spain.
Department of Pediatrics, Hospital General de Tomelloso, Tomelloso, Spain.

Verónica Martín-Dominguez (V)

Instituto de Investigación Sanitaria La Princesa, Madrid, Spain.
Department of Gastroenterology, Hospital Universitario de La Princesa, Madrid, Spain.

Jennifer Fernández-Pacheco (J)

Instituto de Investigación Sanitaria La Princesa, Madrid, Spain.
Department of Gastroenterology, Hospital Universitario de La Princesa, Madrid, Spain.

Maria Teresa Pérez-Fernández (MT)

Instituto de Investigación Sanitaria La Princesa, Madrid, Spain.
Department of Gastroenterology, Hospital Universitario de La Princesa, Madrid, Spain.

Matteo Ghisa (M)

Gastroenterology Unit, Azienza Ospedaliera di Padova, Padova, Italy.

Daria Maniero (D)

Gastroenterology Unit, Azienza Ospedaliera di Padova, Padova, Italy.

Óscar Nantes-Castillejo (Ó)

Department of Gastroenterology, Hospital Universitario de Navarra, Pamplona, Spain.

Julia Nicolay-Maneru (J)

Department of Gastroenterology, Hospital Universitario de Navarra, Pamplona, Spain.

Adolfo Suárez (A)

Department of Gastroenterology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Diet, Microbiota and Health Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.

Iván Maray (I)

Department of Pharmacy, Hospital Universitario Central de Asturias, Oviedo, Spain.

Ronald Llerena-Castro (R)

Department of Gastroenterology, Hospital Universitario Valld'Hebrón, Barcelona, Spain.

Adriana Ortega-Larrodé (A)

Department of Gastroenterology, Fundación Jiménez Díaz, Madrid, Spain.

Javier Alcedo (J)

Department of Gastroenterology, Hospital Universitario Miguel Servet, Zaragoza, Spain.

Alicia Granja Navacerrada (A)

Department of Gastroenterology, Hospital Universitario de Fuenlabrada, Fuenlabrada, Spain.

Francesca Racca (F)

Personalized Medicine, Asthma and Allergy Clinic, IRCCS Humanitas Research Hospital, Rozzano, Italy.

Cecilio Santander (C)

Instituto de Investigación Sanitaria La Princesa, Madrid, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain.
Department of Gastroenterology, Hospital Universitario de La Princesa, Madrid, Spain.

Ángel Arias (Á)

Instituto de Investigación Sanitaria La Princesa, Madrid, Spain.
Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Madrid, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain.
Research Unit, Hospital General Mancha-Centro, Alcázar de San Juan, Spain.

Alfredo J Lucendo (AJ)

Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain.
Instituto de Investigación Sanitaria La Princesa, Madrid, Spain.
Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Madrid, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain.

Classifications MeSH