Spinal cord injury: Olfactory ensheathing cell-based therapeutic strategies.
cell transplantation
central nervous system
regenerative medicine
Journal
Journal of neuroscience research
ISSN: 1097-4547
Titre abrégé: J Neurosci Res
Pays: United States
ID NLM: 7600111
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
revised:
22
08
2023
received:
25
03
2023
accepted:
16
11
2023
medline:
29
1
2024
pubmed:
29
1
2024
entrez:
29
1
2024
Statut:
ppublish
Résumé
Spinal cord injury (SCI) is a highly disabling neurological disorder that is difficult to treat due to its complex pathophysiology and nerve regeneration difficulties. Hence, effective SCI treatments are necessary. Olfactory ensheathing cells (OECs), glial cells derived from the olfactory bulb or mucosa, are ideal candidates for SCI treatment because of their neuroprotective and regenerative properties, ample supply, and convenience. In vitro, animal model, and human trial studies have reported discoveries on OEC transplantation; however, shortcomings have also been demonstrated. Recent studies have optimized various OEC transplantation strategies, including drug integration, biomaterials, and gene editing. This review aims to introduce OECs mechanisms in repairing SCI, summarize the research progress of OEC transplantation-optimized strategies, and provide novel research ideas for SCI treatment.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e25283Subventions
Organisme : Medical Innovation Science and Technology Project of Fujian Province
Organisme : Science and Technology Bureau Project of Quanzhou
Organisme : the Natural Science Foundation of Fujian Province
Informations de copyright
© 2023 Wiley Periodicals LLC.
Références
Ahuja, C. S., Wilson, J. R., Nori, S., Kotter, M. R. N., Druschel, C., Curt, A., & Fehlings, M. G. (2017). Traumatic spinal cord injury. Nature Reviews. Disease Primers, 3, 17018.
Andrews, P. J., Poirrier, A. L., Lund, V. J., & Choi, D. (2016). Safety of human olfactory mucosal biopsy for the purpose of olfactory ensheathing cell harvest and nerve repair: A prospective controlled study in patients undergoing endoscopic sinus surgery. Rhinology, 54(2), 183-191.
Andries, L., van Hove, I., Moons, L., & de Groef, L. (2017). Matrix Metalloproteinases during axonal regeneration, a multifactorial role from start to finish. Molecular Neurobiology, 54(3), 2114-2125.
Assinck, P., Duncan, G. J., Hilton, B. J., Plemel, J. R., & Tetzlaff, W. (2017). Cell transplantation therapy for spinal cord injury. Nature Neuroscience, 20(5), 637-647.
Assunção Silva, R. C., Pinto, L., & Salgado, A. J. (2021). Cell transplantation and secretome based approaches in spinal cord injury regenerative medicine. Medicinal Research Reviews, 42, 850-896.
Bartlett, R. D., Phillips, J. B., & Choi, D. (2019). Improved cell-purification techniques and safety monitoring needed for olfactory ensheathing cell transplantation. CMAJ, 191(43), E1199.
Beiersdorfer, A., Scheller, A., Kirchhoff, F., & Lohr, C. (2019). Panglial gap junctions between astrocytes and olfactory ensheathing cells mediate transmission of Ca transients and neurovascular coupling. Glia, 67(7), 1385-1400.
Bonfanti, R., Musumeci, T., Russo, C., & Pellitteri, R. (2017). The protective effect of curcumin in olfactory ensheathing cells exposed to hypoxia. European Journal of Pharmacology, 796, 62-68.
Campos, F. S. O., Piña-Rodrigues, F. M., Reis, A., Atella, G. C., Mermelstein, C. S., Allodi, S., & Cavalcante, L. A. (2021). Lipid rafts from olfactory ensheathing cells: Molecular composition and possible roles. Cellular and Molecular Neurobiology, 41(3), 525-536.
Chen, K. S., McIntyre, J. C., Lieberman, A. P., Martens, J. R., & Patil, P. G. (2016). Human spinal autografts of olfactory epithelial stem cells recapitulate donor site histology, maintaining proliferative and differentiation capacity many years after transplantation. Acta Neuropathologica, 131(4), 639-640.
Chen, L., Huang, H., Xi, H., Zhang, F., Liu, Y., Chen, D., & Xiao, J. (2014). A prospective randomized double-blind clinical trial using a combination of olfactory ensheathing cells and Schwann cells for the treatment of chronic complete spinal cord injuries. Cell Transplantation, 23(Suppl 1), S35-S44.
Collins, A., Ibrahim, A., Li, D., Olushanu, M., & Li, Y. (2019). Reconstruction of the damaged dorsal root entry zone by transplantation of olfactory ensheathing cells. Cell Transplantation, 28(9-10), 1212-1219.
Coutts, D. J. C., Humphries, C. E., Zhao, C., Plant, G. W., & Franklin, R. J. M. (2013). Embryonic-derived olfactory ensheathing cells remyelinate focal areas of spinal cord demyelination more efficiently than neonatal or adult-derived cells. Cell Transplantation, 22(7), 1249-1261.
Delaney, A. M., Adams, C. F., Fernandes, A. R., al-Shakli, A. F., Sen, J., Carwardine, D. R., Granger, N., & Chari, D. M. (2017). A fusion of minicircle DNA and nanoparticle delivery technologies facilitates therapeutic genetic engineering of autologous canine olfactory mucosal cells. Nanoscale, 9(25), 8560-8566.
Delarue, Q., Mayeur, A., Chalfouh, C., Honoré, A., Duclos, C., di Giovanni, M., Li, X., Salaun, M., Dampierre, J., Vaudry, D., Marie, J. P., & Guérout, N. (2020). Inhibition of ADAMTS-4 expression in olfactory ensheathing cells enhances recovery after transplantation within spinal cord injury. Journal of Neurotrauma, 37(3), 507-516.
Delarue, Q., Robac, A., Massardier, R., Marie, J. P., & Guérout, N. (2021). Comparison of the effects of two therapeutic strategies based on olfactory ensheathing cell transplantation and repetitive magnetic stimulation after spinal cord injury in female mice. Journal of Neuroscience Research, 99(7), 1835-1849.
Fan, B., Wei, Z., & Feng, S. (2022). Progression in translational research on spinal cord injury based on microenvironment imbalance. Bone Research, 10(1), 35.
Gao, Z., Zhao, Y., He, X., Leng, Z., Zhou, X., Song, H., Wang, R., Gao, Z., Wang, Y., Liu, J., & Niu, B. (2020). Transplantation of sh-miR-199a-5p-modified olfactory Ensheathing cells promotes the functional recovery in rats with contusive spinal cord injury. Cell Transplantation, 29, 963689720916173.
GBD 2016 Neurology Collaborators. (2019). Global, regional, and national burden of neurological disorders, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, 18(5), 459-480.
Ge, L., Liu, K., Liu, Z., & Lu, M. (2016). Co-transplantation of autologous OM-MSCs and OM-OECs: A novel approach for spinal cord injury. Reviews in the Neurosciences, 27(3), 259-270.
Ge, L., Zhang, C., Xie, H., Zhuo, Y., Xun, C., Chen, P., Hu, Z., & Lu, M. (2021). A phosphoproteomics study reveals a defined genetic program for neural lineage commitment of neural stem cells induced by olfactory ensheathing cell-conditioned medium. Pharmacological Research, 172, 105797.
Gilmour, A. D., Reshamwala, R., Wright, A. A., Ekberg, J. A. K., & St John, J. A. (2020). Optimizing olfactory ensheathing cell transplantation for spinal cord injury repair. Journal of Neurotrauma, 37(5), 817-829.
Gomes, E. D., Mendes, S. S., Assunção-Silva, R. C., Teixeira, F. G., Pires, A. O., Anjo, S. I., Manadas, B., Leite-Almeida, H., Gimble, J. M., Sousa, N., Lepore, A. C., Silva, N. A., & Salgado, A. J. (2018). Co-transplantation of adipose tissue-derived stromal cells and olfactory ensheathing cells for spinal cord injury repair. Stem Cells (Dayton, Ohio), 36(5), 696-708.
Gomes, E. D., Mendes, S. S., Leite-Almeida, H., Gimble, J. M., Tam, R. Y., Shoichet, M. S., Sousa, N., Silva, N. A., & Salgado, A. J. (2016). Combination of a peptide-modified gellan gum hydrogel with cell therapy in a lumbar spinal cord injury animal model. Biomaterials, 105, 38-51.
Greiner, N., Barra, B., Schiavone, G., Lorach, H., James, N., Conti, S., Kaeser, M., Fallegger, F., Borgognon, S., Lacour, S., Bloch, J., Courtine, G., & Capogrosso, M. (2021). Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord. Nature Communications, 12(1), 435.
Guo, J., Cao, G., Yang, G., Zhang, Y., Wang, Y., Song, W., Xu, Y., Ma, T., Liu, R., Zhang, Q., Hao, D., & Yang, H. (2020). Transplantation of activated olfactory ensheathing cells by curcumin strengthens regeneration and recovery of function after spinal cord injury in rats. Cytotherapy, 22(6), 301-312.
Han, Q., Ordaz, J. D., Liu, N. K., Richardson, Z., Wu, W., Xia, Y., Qu, W., Wang, Y., Dai, H., Zhang, Y. P., Shields, C. B., Smith, G. M., & Xu, X. M. (2019). Descending motor circuitry required for NT-3 mediated locomotor recovery after spinal cord injury in mice. Nature Communications, 10(1), 5815.
Hao, D.-J., Liu, C., Zhang, L., Chen, B., Zhang, Q., Zhang, R., An, J., Zhao, J., Wu, M., Wang, Y., Simental, A., He, B., & Yang, H. (2017). Lipopolysaccharide and curcumin co-stimulation potentiates olfactory ensheathing cell phagocytosis via enhancing their activation. Neurotherapeutics, 14(2), 502-518.
Hassarati, R. T., Foster, L. J. R., & Green, R. A. (2016). Influence of biphasic stimulation on olfactory ensheathing cells for neuroprosthetic devices. Frontiers in Neuroscience, 10, 432.
Hu, X.-C., Lu, Y. B., Yang, Y. N., Kang, X. W., Wang, Y. G., Ma, B., & Xing, S. (2021). Progress in clinical trials of cell transplantation for the treatment of spinal cord injury: How many questions remain unanswered? Neural Regeneration Research, 16(3), 405-413.
Huang, Z.-H., & Liu, Y.b. (2017). Spinal cord injuries and repairs: research progress and prospects. Chinese Journal of Pharmacology and Toxicology, 31(12), 1155-1168.
Hutson, T. H., & Di Giovanni, S. (2019). The translational landscape in spinal cord injury: Focus on neuroplasticity and regeneration. Nature Reviews. Neurology, 15(12), 732-745.
Ingram, N. T., Khankan, R. R., & Phelps, P. E. (2016). Olfactory ensheathing cells express α7 integrin to mediate their migration on Laminin. PLoS One, 11(4), e0153394.
Karsy, M., & Hawryluk, G. (2019). Modern medical management of spinal cord injury. Current Neurology and Neuroscience Reports, 19(9), 65.
Katoh, H., Yokota, K., & Fehlings, M. G. (2019). Regeneration of spinal cord connectivity through stem cell transplantation and biomaterial scaffolds. Frontiers in Cellular Neuroscience, 13, 248.
Keefe, K. M., Sheikh, I. S., & Smith, G. M. (2017). Targeting Neurotrophins to specific populations of neurons: NGF, BDNF, and NT-3 and their relevance for treatment of spinal cord injury. International Journal of Molecular Sciences, 18(3), 548.
Khankan, R. R., Griffis, K. G., Haggerty-Skeans, J. R., Zhong, H., Roy, R. R., Edgerton, V. R., & Phelps, P. E. (2016). Olfactory ensheathing cell transplantation after a complete spinal cord transection mediates neuroprotective and immunomodulatory mechanisms to facilitate regeneration. The Journal of Neuroscience, 36(23), 6269-6286.
Liu, T., Ji, Z., Ahsan, S., Zhang, Y., Zhang, P., Fan, Z., & Shen, Y. (2017). Intrathecal transplantation of olfactory ensheathing cells by lumbar puncture for thoracic spinal cord injury in mice. Journal of Neurorestoratology, 5, 103-109.
Marycz, K., Marędziak, M., Grzesiak, J., Szarek, D., Lis, A., & Laska, J. (2016). Polyurethane/polylactide-blend films doped with zinc ions for the growth and expansion of human olfactory ensheathing cells (OECs) and adipose-derived mesenchymal stromal stem cells (ASCs) for regenerative medicine applications. Polymers, 8(5), 175.
Minev, I. R., Musienko, P., Hirsch, A., Barraud, Q., Wenger, N., Moraud, E. M., Gandar, J., Capogrosso, M., Milekovic, T., Asboth, L., & Torres, R. F. (2015). Biomaterials. Electronic dura mater for long-term multimodal neural interfaces. Science (New York, N.Y.), 347(6218), 159-163.
Nakhjavan-Shahraki, B., Yousefifard, M., Rahimi-Movaghar, V., Baikpour, M., Nasirinezhad, F., Safari, S., Yaseri, M., Moghadas Jafari, A., Ghelichkhani, P., Tafakhori, A., & Hosseini, M. (2018). Transplantation of olfactory ensheathing cells on functional recovery and neuropathic pain after spinal cord injury; systematic review and meta-analysis. Scientific Reports, 8(1), 325.
Papastefanaki, F., & Matsas, R. (2015). From demyelination to remyelination: The road toward therapies for spinal cord injury. Glia, 63(7), 1101-1125.
Pellitteri, R., Russo, A., Stanzani, S., & Zaccheo, D. (2015). Olfactory ensheathing cells protect cortical neuron cultures exposed to hypoxia. CNS & Neurological Disorders Drug Targets, 14(1), 68-76.
Pourkhodadad, S., Oryan, S. H., Kaka, G., & Sadraie, S. H. (2019). Neuroprotective effects of combined treatment with minocycline and olfactory ensheathing cells transplantation against inflammation and oxidative stress after spinal cord injury. Cell Journal, 21(2), 220-228.
Prager, J., Adams, C. F., Delaney, A. M., Chanoit, G., Tarlton, J. F., Wong, L. F., Chari, D. M., & Granger, N. (2020). Stiffness-matched biomaterial implants for cell delivery: Clinical, intraoperative ultrasound elastography provides a ‘target’ stiffness for hydrogel synthesis in spinal cord injury. Journal of Tissue Engineering, 11, 2041731420934806.
Prager, J., Ito, D., Carwardine, D. R., Jiju, P., Chari, D. M., Granger, N., & Wong, L. F. (2021). Delivery of chondroitinase by canine mucosal olfactory ensheathing cells alongside rehabilitation enhances recovery after spinal cord injury. Experimental Neurology, 340, 113660.
Quadri, S. A., Farooqui, M., Ikram, A., Zafar, A., Khan, M. A., Suriya, S. S., Claus, C. F., Fiani, B., Rahman, M., Ramachandran, A., Armstrong, I. I. T., Taqi, M. A., & Mortazavi, M. M. (2020). Recent update on basic mechanisms of spinal cord injury. Neurosurgical Review, 43(2), 425-441.
Reshamwala, R., Shah, M., St John, J., & Ekberg, J. (2019). Survival and integration of transplanted olfactory ensheathing cells are crucial for spinal cord injury repair: Insights from the last 10 years of animal model studies. Cell Transplantation, 28(1_suppl), 132S-159S.
Rigby, M. J., Gomez, T. M., & Puglielli, L. (2020). Glial cell-axonal growth cone interactions in neurodevelopment and regeneration. Frontiers in Neuroscience, 14, 203.
Rowald, A., Komi, S., Demesmaeker, R., Baaklini, E., Hernandez-Charpak, S. D., Paoles, E., Montanaro, H., Cassara, A., Becce, F., Lloyd, B., Newton, T., Ravier, J., Kinany, N., D'Ercole, M., Paley, A., Hankov, N., Varescon, C., McCracken, L., Vat, M., … Courtine, G. (2022). Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis. Nature Medicine, 28(2), 260-271.
Stepanova, O. V., Voronova, A. D., Sosnovtseva, A. O., Stepanenko, A. A., Chadin, A. V., Karsuntseva, E. K., Fursa, G. A., Valikhov, M. P., Semkina, A. S., Vorobyev, P. O., Reshetov, I. V., & Chekhonin, V. P. (2022). Study of the therapeutic efficiency of transduced olfactory ensheathing cells in spinal cord cysts. Stem Cells and Development, 31(1-2), 9-17.
Tabakow, P., Jarmundowicz, W., Czapiga, B., Fortuna, W., Miedzybrodzki, R., Czyz, M., Huber, J., Szarek, D., Okurowski, S., Szewczyk, P., Gorski, A., & Raisman, G. (2013). Transplantation of autologous olfactory ensheathing cells in complete human spinal cord injury. Cell Transplantation, 22(9), 1591-1612.
Thornton, M. A., Mehta, M. D., Morad, T. T., Ingraham, K. L., Khankan, R. R., Griffis, K. G., Yeung, A. K., Zhong, H., Roy, R. R., Edgerton, V. R., & Phelps, P. E. (2018). Evidence of axon connectivity across a spinal cord transection in rats treated with epidural stimulation and motor training combined with olfactory ensheathing cell transplantation. Experimental Neurology, 309, 119-133.
Tsai, M.-J., Huang, C. T., Huang, Y. S., Weng, C. F., Shyue, S. K., Huang, M. C., Liou, D. Y., Lin, Y. R., Cheng, C. H., Kuo, H. S., Lin, Y., Lee, M. J., Huang, W. H., Huang, W. C., & Cheng, H. (2017). Improving the regenerative potential of olfactory ensheathing cells by overexpressing prostacyclin synthetase and its application in spinal cord repair. Journal of Biomedical Science, 24(1), 34.
Tseng, Y.-T., Chen, M., Lai, R., Oieni, F., Smyth, G., Anoopkumar-Dukie, S., St John, J., & Ekberg, J. (2021). Liraglutide modulates olfactory ensheathing cell migration with activation of ERK and alteration of the extracellular matrix. Biomedicine & Pharmacotherapy, 141, 111819.
Ursavas, S., Darici, H., & Karaoz, E. (2021). Olfactory ensheathing cells: Unique glial cells promising for treatments of spinal cord injury. Journal of Neuroscience Research, 99(6), 1579-1597.
Vadivelu, R. K., Ooi, C. H., Yao, R. Q., Tello Velasquez, J., Pastrana, E., Diaz-Nido, J., Lim, F., Ekberg, J. A. K., Nguyen, N. T., & St John, J. A. (2015). Generation of three-dimensional multiple spheroid model of olfactory ensheathing cells using floating liquid marbles. Scientific Reports, 5, 15083.
Walker, M. J., & Xu, X.-M. (2018). History of glial cell line-derived neurotrophic factor (GDNF) and its use for spinal cord injury repair. Brain Sciences, 8(6), 109.
Wang, G.-Y., Cheng, Z. J., Yuan, P. W., Li, H. P., & He, X. J. (2021). Olfactory ensheathing cell transplantation alters the expression of chondroitin sulfate proteoglycans and promotes axonal regeneration after spinal cord injury. Neural Regeneration Research, 16(8), 1638-1644.
Wang, X., Kuang, N., Chen, Y., Liu, G., Wang, N., Kong, F., Yue, S., & Zheng, Z. (2021). Transplantation of olfactory ensheathing cells promotes the therapeutic effect of neural stem cells on spinal cord injury by inhibiting necrioptosis. Aging, 13(6), 9056-9070.
Wang, Y., Teng, H. L., Gao, Y., Zhang, F., Ding, Y. Q., & Huang, Z. H. (2016). Brain-derived neurotrophic factor promotes the migration of olfactory ensheathing cells through TRPC channels. Glia, 64(12), 2154-2165.
Woodworth, C. F., Jenkins, G., Barron, J., & Hache, N. (2019). Intramedullary cervical spinal mass after stem cell transplantation using an olfactory mucosal cell autograft. CMAJ, 191(27), E761-E764.
Wright, A. A., Todorovic, M., Murtaza, M., St John, J. A., & Ekberg, J. A. (2020). Macrophage migration inhibitory factor and its binding partner HTRA1 are expressed by olfactory ensheathing cells. Molecular and Cellular Neurosciences, 102, 103450.
Wright, A. A., Todorovic, M., Tello-Velasquez, J., Rayfield, A. J., St John, J. A., & Ekberg, J. A. (2018). Enhancing the therapeutic potential of olfactory ensheathing cells in spinal cord repair using Neurotrophins. Cell Transplantation, 27(6), 867-878.
Wu, J., Sun, T., Ye, C., Yao, J., Zhu, B., & He, H. (2012). Clinical observation of fetal olfactory ensheathing glia transplantation (OEGT) in patients with complete chronic spinal cord injury. Cell Transplantation, 21(Suppl 1), S33-S37.
Wu, S., Cui, G., Shao, H., Du, Z., Ng, J. C., & Peng, C. (2015). The cotransplantation of olfactory ensheathing cells with bone marrow mesenchymal stem cells exerts antiapoptotic effects in adult rats after spinal cord injury. Stem Cells International, 2015, 516215.
Xie, J., Li, Y., Dai, J., He, Y., Sun, D., Dai, C., Xu, H., & Yin, Z. Q. (2019). Olfactory ensheathing cells grafted into the retina of RCS rats suppress inflammation by down-regulating the JAK/STAT pathway. Frontiers in Cellular Neuroscience, 13, 341.
Yang, H., He, B.-R., & Hao, D.-J. (2015). Biological roles of olfactory ensheathing cells in facilitating neural regeneration: A systematic review. Molecular Neurobiology, 51(1), 168-179.
Yao, R., Murtaza, M., Velasquez, J. T., Todorovic, M., Rayfield, A., Ekberg, J., Barton, M., & St John, J. (2018). Olfactory ensheathing cells for spinal cord injury: Sniffing out the issues. Cell Transplantation, 27(6), 879-889.
Yu, F., Li, P., du, S., Lui, K. H. W., Lin, Y., Chen, L., Ren, Q., Wang, J., Mei, J., Xiao, J., & Zhu, J. (2021). Olfactory ensheathing cells seeded decellularized scaffold promotes axonal regeneration in spinal cord injury rats. Journal of Biomedical Materials Research. Part A, 109(5), 779-787.
Yui, S., Fujita, N., Chung, C.-S., Morita, M., & Nishimura, R. (2014). Olfactory ensheathing cells (OECs) degrade neurocan in injured spinal cord by secreting matrix metalloproteinase-2 in a rat contusion model. The Japanese Journal of Veterinary Research, 62(4), 151-162.
Zawadzka, M., Kwaśniewska, A., Miazga, K., & Sławińska, U. (2021). Perspectives in the cell-based therapies of various aspects of the spinal cord injury-associated pathologies: Lessons from the animal models. Cells, 10(11), 2995.
Zhang, J., Chen, H., Duan, Z., Chen, K., Liu, Z., Zhang, L., Yao, D., & Li, B. (2017). The effects of co-transplantation of olfactory ensheathing cells and Schwann cells on local inflammation environment in the contused spinal cord of rats. Molecular Neurobiology, 54(2), 943-953.
Zhang, L., Li, B., Liu, B., & Dong, Z. (2019). Co-transplantation of epidermal neural crest stem cells and olfactory ensheathing cells repairs sciatic nerve defects in rats. Frontiers in Cellular Neuroscience, 13, 253.
Zhang, L., Zhuang, X., Kotitalo, P., Keller, T., Krzyczmonik, A., Haaparanta-Solin, M., Solin, O., Forsback, S., Grönroos, T. J., Han, C., López-Picón, F. R., & Xia, H. (2021). Intravenous transplantation of olfactory ensheathing cells reduces neuroinflammation after spinal cord injury interleukin-1 receptor antagonist. Theranostics, 11(3), 1147-1161.
Zhang, W.-J., Luo, H. L., Zhu, J. F., Hu, C. G., & Zhu, Z. M. (2020). Transplantation of olfactory ensheathing cells combined with chitosan down-regulates the expression of P2X7 receptor in the spinal cord and inhibits neuropathic pain. Brain Research, 1748, 147058.
Zhang, Y., Yang, S., Liu, C., Han, X., Gu, X., & Zhou, S. (2021). Deciphering glial scar after spinal cord injury. Burns & Trauma, 9, tkab035.
Zheng, C.-G., Zhang, F., Bao, X. M., Wu, S. Y., Wang, P., Zhou, J. N., Gao, Y., Teng, H. L., Wang, Y., & Huang, Z. H. (2017). Polarized distribution of active myosin II regulates directional migration of cultured olfactory ensheathing cells. Scientific Reports, 7(1), 4701.
Zhong, W., Bian, K., Hu, Y., Ji, Z., Xu, X., Li, J., Wu, P., Wang, X., Zhang, Y., Zhang, P., Zhang, H., & Shen, Y. (2019). Lysophosphatidic acid guides the homing of transplanted olfactory ensheathing cells to the lesion site after spinal cord injury in rats. Experimental Cell Research, 379(1), 65-72.
Zipser, C. M., Cragg, J. J., Guest, J. D., Fehlings, M. G., Jutzeler, C. R., Anderson, A. J., & Curt, A. (2022). Cell-based and stem-cell-based treatments for spinal cord injury: Evidence from clinical trials. The Lancet Neurology, 21, 659-670.