Ac-DEVD-CHO (caspase-3/DEVDase inhibitor) suppresses self-incompatibility-induced programmed cell death in the pollen tubes of petunia (Petunia hybrida E. Vilm.).
Journal
Cell death discovery
ISSN: 2058-7716
Titre abrégé: Cell Death Discov
Pays: United States
ID NLM: 101665035
Informations de publication
Date de publication:
30 Jan 2024
30 Jan 2024
Historique:
received:
08
11
2023
accepted:
15
01
2024
revised:
11
01
2024
medline:
30
1
2024
pubmed:
30
1
2024
entrez:
29
1
2024
Statut:
epublish
Résumé
Programmed cell death (PCD) is relevant to many aspects in the growth and development of a plant organism. In their reproduction, many flowering plant species possess self-incompatibility (SI), that is an intraspecific reproductive barrier, which is a genetic mechanism ensuring the avoidance of inbreeding depression by preventing self-pollination. This phenomenon enhances intraspecific variation; however, SI is rather a hindrance for some fruit plant species (such as plum, cherry, and peer trees) rather than an advantage in farming. PCD is a factor of the S-RNase-based SI in Petunia hybrida E. Vilm. The growth of self-incompatible pollen tubes (PTs) is arrested with an increase in the activity of caspase-like proteases during the first hours after pollination so that all traits of PCD-plasma membrane integrity damage, DNA degradation/disintegration, and damage of PT structural organization (absence of vacuoles, turgor disturbance, and separation of cell plasma membrane from the cell wall)-are observable by the moment of PT growth arrest. We succeeded in discovering an additional cytological PCD marker, namely, the formation of ricinosomes in self-incompatible PTs at early stages of PCD. SI is removable by treating petunia stigmas with Acetyl-Asp-Glu-Val-Asp-aldehyde (Ac-DEVD-CHO), an inhibitor of caspase-3/DEVDase, 2 h before a self-incompatible pollination. In this process, the level of caspase-3-like protease activity was low, DNA degradation was absent, PTs grew to the ovary, fertilization was successful, and full-fledged seeds were formed.
Identifiants
pubmed: 38287001
doi: 10.1038/s41420-024-01821-x
pii: 10.1038/s41420-024-01821-x
doi:
Types de publication
Journal Article
Langues
eng
Pagination
59Subventions
Organisme : Russian Science Foundation (RSF)
ID : 22-24-01148
Organisme : Russian Science Foundation (RSF)
ID : 22-24-01148
Organisme : Russian Science Foundation (RSF)
ID : 22-24-01148
Organisme : Russian Science Foundation (RSF)
ID : 22-24-01148
Organisme : Russian Science Foundation (RSF)
ID : 22-24-01148
Organisme : Russian Science Foundation (RSF)
ID : 22-24-01148
Informations de copyright
© 2024. The Author(s).
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