Sphingosine 1-phosphate signaling axis mediates neuropeptide S-induced invasive phenotype of endometriotic cells.
Rho
cellular migration
endometriosis non-hormonal treatment
neuropeptide S
sphingosine 1-phosphate receptors
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
29 Jan 2024
29 Jan 2024
Historique:
revised:
12
12
2023
received:
14
08
2023
accepted:
09
01
2024
medline:
30
1
2024
pubmed:
30
1
2024
entrez:
29
1
2024
Statut:
aheadofprint
Résumé
Endometriosis is a chronic gynecological syndrome characterized by endometrial cell invasion of the extra-uterine milieu, pelvic pain and infertility. Treatment relies on either symptomatic drugs or hormonal therapies, even though the mechanism involved in the onset of endometriosis is yet to be elucidated. The signaling of sphingolipid sphingosine 1-phosphate (S1P) is profoundly dysregulated in endometriosis. Indeed, sphingosine kinase (SK)1, one of the two isoenzymes responsible for S1P biosynthesis, and S1P
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fondazione Cassa di Risparmio di Firenze
Organisme : Fondi di Ateneo
Organisme : Fondazione Careggi
Organisme : Italian Ministry of Education University and Research
Organisme : Progetto Medicina di Genere
Informations de copyright
© 2024 Federation of European Biochemical Societies.
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