De novo male breast metastases from nasopharyngeal carcinoma: a case report.
Breast
Male
Nasopharynx
Synchronous metastasis
Undifferentiated carcinoma
Journal
Journal of medical case reports
ISSN: 1752-1947
Titre abrégé: J Med Case Rep
Pays: England
ID NLM: 101293382
Informations de publication
Date de publication:
30 Jan 2024
30 Jan 2024
Historique:
received:
14
08
2023
accepted:
03
01
2024
medline:
30
1
2024
pubmed:
30
1
2024
entrez:
30
1
2024
Statut:
epublish
Résumé
Nasopharyngeal carcinoma is known for its high potential for regional and distant metastasis. However, breast metastasis is rarely reported. A 39-year-old Caucasian male presented with bilateral neck lymph node enlargement. Radiological examination with contrast-enhanced computed tomography scan and breast imaging revealed an enhancing mass lesion in the right breast. Histopathology of the nasopharynx mass was suggestive of undifferentiated nasopharyngeal carcinoma. A breast biopsy confirmed the diagnosis of synchronous breast metastasis from the nasopharyngeal carcinoma. We present this study to illustrate that Nasopharyngeal carcinoma can metastasize to the male breast. Furthermore, the high incidence of nasopharyngeal carcinoma metastasis underscores the pressing need to identify effective and safe strategies, emphasizing the importance of utilizing computed tomography scans for metastasis detection. The present study illustrates the first case of synchronous male breast metastases from nasopharyngeal carcinoma. Thus, it is critical to distinguish between metastatic pathology and coexisting second malignancies to plan appropriate therapy.
Sections du résumé
BACKGROUND
BACKGROUND
Nasopharyngeal carcinoma is known for its high potential for regional and distant metastasis. However, breast metastasis is rarely reported.
CASE PRESENTATION
METHODS
A 39-year-old Caucasian male presented with bilateral neck lymph node enlargement. Radiological examination with contrast-enhanced computed tomography scan and breast imaging revealed an enhancing mass lesion in the right breast. Histopathology of the nasopharynx mass was suggestive of undifferentiated nasopharyngeal carcinoma. A breast biopsy confirmed the diagnosis of synchronous breast metastasis from the nasopharyngeal carcinoma. We present this study to illustrate that Nasopharyngeal carcinoma can metastasize to the male breast. Furthermore, the high incidence of nasopharyngeal carcinoma metastasis underscores the pressing need to identify effective and safe strategies, emphasizing the importance of utilizing computed tomography scans for metastasis detection.
CONCLUSION
CONCLUSIONS
The present study illustrates the first case of synchronous male breast metastases from nasopharyngeal carcinoma. Thus, it is critical to distinguish between metastatic pathology and coexisting second malignancies to plan appropriate therapy.
Identifiants
pubmed: 38287377
doi: 10.1186/s13256-024-04353-1
pii: 10.1186/s13256-024-04353-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
36Informations de copyright
© 2024. The Author(s).
Références
Kaidar-Person O, Kuten J, Atrash F, Billan S, Kuten A. Brain metastasis of nasopharyngeal carcinoma: a case report and literature review. Case Rep Med. 2012;2012:e405917.
doi: 10.1155/2012/405917
Li S, Yang J. Nasopharyngealcarcinomametastasis to the mammarygland: a case report. Oncol Lett. 2015;9(1):275–7.
doi: 10.3892/ol.2014.2656
pubmed: 25435974
Liang N, Xie J, Liu F, Xu D, Yu X, Tian Y, et al. Male breast metastases from nasopharyngeal carcinoma: a case report and literature review. Oncol Lett. 2014;7(5):1586–8.
doi: 10.3892/ol.2014.1894
pubmed: 24765181
pmcid: 3997684
Leach BI, Sun B, Petrovic L, Liu SV. Breast metastasis from nasopharyngeal carcinoma: a case report and review of the literature. Oncol Lett. 2013;5(6):1859–61.
doi: 10.3892/ol.2013.1303
pubmed: 23833656
pmcid: 3700800
Albasri AM. Nasopharyngeal carcinoma metastasis to the breast. Saudi Med J. 2020;41(10):1130–4.
doi: 10.15537/smj.2020.10.25420
pubmed: 33026055
pmcid: 7841513
Tsung SH. Metastasis of colon cancer to the breast. Case Rep Oncol. 2017;10(1):77–80.
doi: 10.1159/000455225
pubmed: 28203167
pmcid: 5301093
Mun SH, Ko EY, Han BK, Shin JH, Kim SJ, Cho EY. Breast metastases from extra mammary malignancies: typical and atypical ultrasound features. Korean J Radiol. 2014;15(1):20–8.
doi: 10.3348/kjr.2014.15.1.20
pubmed: 24497788
pmcid: 3909857
Kapoor A, Kalwar A, Kumar N, Maharia S, Nirban R, Kumar H. Detection of bone metastasis in nasopharyngeal carcinoma by bone scintigraphy: a retrospective study in perspective of limitedresource settings. Clin Cancer Investig J. 2015;4(1):17.
doi: 10.4103/2278-0513.149027
Pai T, Nair N, Pantvaidya G, Deodhar K, Shet T. Metastatic nasopharyngeal carcinoma presenting as an isolated breast mass: a diagnostic pitfall and a review of literature. Indian J Pathol Microbiol. 2017;60(1):119.
pubmed: 28195109
Soni SV, Malhotra V, Sharma R, Singh M, Dixit R, Mallya V. Nasopharyngeal carcinoma with bilateral breast metastasis: a report of an elusive case. Cureus. 2022;14(7):e27497.
pubmed: 36060330
pmcid: 9424790
Qu W, Li S, Zhang M, Qiao Q. Pattern and prognosis of distant metastases in nasopharyngeal carcinoma: a large-population retrospective analysis. Cancer Med. 2020;9(17):6147–58.
doi: 10.1002/cam4.3301
pubmed: 32649056
pmcid: 7476823
Aribas BK, Onursever A, Kiziltepe TT, Aydin H, Cosar S, Sahin B, et al. Breast metastasis from rectal adenocarcinoma: a case report with US and CT findings. Imaging Med. 2016;8(3):89–92.
Toumi N, Ennouri S, Charfeddine I, Daoud J, Khanfir A. Prognostic factors in metastatic nasopharyngeal carcinoma. Braz J Otorhinolaryngol. 2022;88(2):212–9.
doi: 10.1016/j.bjorl.2020.05.022
pubmed: 32690385
Chen MY, Jiang R, Guo L, Zou X, Liu Q, Sun R, et al. Loco regional radiotherapy in patients with distant metastases of nasopharyngeal carcinoma at diagnosis. Chin J Cancer. 2013;32(11):604–13.
doi: 10.5732/cjc.013.10148
pubmed: 24206918
pmcid: 3845550
Lin S, Tham IWK, Pan J, Han L, Chen Q, Lu JJ. Combined high-dose radiation therapy and systemic chemotherapy improves survival in patients with newly diagnosed metastatic nasopharyngeal cancer. Am J Clin Oncol. 2012;35(5):474.
doi: 10.1097/COC.0b013e31821a9452
pubmed: 21577086
You R, Liu YP, Huang PY, Zou X, Sun R, He YX, et al. Efficacy and safety of loco regional radiotherapy with chemotherapy vs chemotherapy alone in de novo metastatic nasopharyngeal carcinoma: a multicenter phase 3 randomized clinical trial. JAMA Oncol. 2020;6(9):1345–52.
doi: 10.1001/jamaoncol.2020.1808
pubmed: 32701129
pmcid: 7378870