Advancing the implementation of take-home naloxone by community pharmacists: Testing the role of COM-B.

implementation science naloxone opiate overdose pharmacy theoretical model

Journal

Drug and alcohol review
ISSN: 1465-3362
Titre abrégé: Drug Alcohol Rev
Pays: Australia
ID NLM: 9015440

Informations de publication

Date de publication:
29 Jan 2024
Historique:
revised: 05 12 2023
received: 22 05 2023
accepted: 08 12 2023
medline: 30 1 2024
pubmed: 30 1 2024
entrez: 30 1 2024
Statut: aheadofprint

Résumé

Opioid-related overdose fatalities are rising despite the increased accessibility of take-home naloxone (THN). Targeted implementation strategies are needed to improve the distribution of naloxone. This study investigates the effectiveness of a short video targeting pharmacists that addresses implementation barriers. A pre-post, mixed methods design was adopted to examine the effect of a brief behaviour change intervention (an educational video informed by the capability, opportunity, motivation affecting behaviour (COM-B) model), on factors affecting pharmacists' implementation of THN in Western Australia. Paired samples t-tests for were used to investigate intentions, knowledge, skill, confidence, feasibility, appropriateness, acceptability, attitudes, anticipated patient reactions, social support and implementation climate. Structural equation modelling examined the associations between constructs and to test the proposed mediation of motivation on capability and opportunity affecting intentions to discuss and provide THN. We analysed data from 102 participants. At follow-up and after all participants had viewed the video, participants had significantly improved intentions, skill, confidence, anticipated reactions, social support and perceptions that THN implementation was feasible, appropriate and acceptable. No significant differences were seen for attitudes, knowledge or implementation climate. The proposed mediation effect of motivation on the associations between opportunity and intentions and capability and intentions was not supported. A short video directly targeting identified implementation barriers has the ability to improve key influences in the provision of THN. Dissemination of information to community pharmacists is a challenge. Implementation strategies addressing knowledge and targeting other levels of influence on intentions and behaviour are required.

Identifiants

pubmed: 38287683
doi: 10.1111/dar.13805
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Medical Research Future Fund
ID : GNT1168155

Informations de copyright

© 2024 The Authors. Drug and Alcohol Review published by John Wiley & Sons Australia, Ltd on behalf of Australasian Professional Society on Alcohol and other Drugs.

Références

Robert M, Jouanjus E, Khouri C, Fouilhé Sam-Laï N, Revol B. The opioid epidemic: A worldwide exploratory study using the WHO pharmacovigilance database. Addiction. 2023;118:771-775.
Celentano D. The worldwide opioid pandemic: Epidemiologic perspectives. Epidemiol Rev. 2020;42:1-3.
Chrzanowska A, Man N, Sutherland R, Degenhardt L, Peacock A. Trends in Overdose and Other Drug-Induced Deaths in Australia, 1997-2020. 2022.
Australian Institute of Health and Welfare. Alcohol, tobacco & other drugs in Australia. Canberra. 2022.
McDonald R, Strang J. Are take-home naloxone programmes effective? Systematic review utilizing application of the Bradford Hill criteria. Addiction. 2016;111:1177-1187.
Chrzanowska A, Man N, Sutherland R, Degenhardt L, Peacock A. Trends in Overdose and Other Drug-Induced Deaths in Australia, 1997-2020. National Drug & Alcohol Research Centre. 2022. Available from: https://ndarc.med.unsw.edu.au/resource-analytics/trends-drug-induced-deaths-australia-1997-2020
World Health Organization. Community management of opioid overdose. Geneva. 2014.
Dwyer R, Olsen A, Fowlie C, Gough C, van Beek I, Jauncey M, et al. An overview of take-home naloxone programs in Australia. Drug Alcohol Rev. 2018;37:440-449.
Government of Western Australia DoH. Review of Community Pharmacy Ownership in Western Australia-Final Report 2019.
US Department of Health and Human Services. Pharmacists: On The Front Lines Addressing Prescription Opioid Abuse and Overdose.
Muzyk A, Smothers ZPW, Collins K, MacEachern M, Wu LT. Pharmacists' attitudes toward dispensing naloxone and medications for opioid use disorder: A scoping review of the literature. Subst Abus. 2019;40:476-483.
Cid A, Daskalakis G, Grindrod K, Beazely MA. What is known about community pharmacy-based take-home naloxone programs and program interventions? A scoping review. Pharmacy (Basel). 2021;9:30.
Lenton SR, Dietze PM, Jauncey M. Australia reschedules naloxone for opioid overdose. Med J Aust. 2016;204:146-147.
Nielsen S, Olsen A. Using the behaviour change wheel to understand and address barriers to pharmacy naloxone supply in Australia. Int J Drug Policy. 2021;90:103061.
Salom CL, Maravilla JC, Thomas N, Juckel J, Daly C, Peacock A, et al. Evaluation of the Pharmaceutical Benefits Scheme Subsidised Take Home Naloxone Pilot-Final Report. Institute for Social Science Research: The University of Queensland Australia, Brisbane Australia; 2022.
Michie S, Van Stralen MM, West R. The behaviour change wheel: A new method for characterising and designing behaviour change interventions. Implement Sci. 2011;6:42.
Michie S, Atkins L, West R. The behaviour change wheel. A guide to designing interventions. Great Britain: Silverback Publishing; 2014. p. 1003-1010.
West R, Michie S. A brief introduction to the COM-B Model of behaviour and the PRIME Theory of motivation. 2020. Report No. 2632-3834.
Straker K, Wrigley C. (eds) Research Handbook on Design Thinking. Cheltenham, UK: Edward Elgar Publishing; 2023.
Qualtrics. Qualtrics. 2005 Available from: https://www.qualtrics.com
Moullin JC, Ehrhart MG, Aarons GA. Development and testing of the Measure of Innovation-Specific Implementation Intentions (MISII) using Rasch measurement theory. Implement Sci. 2018;13:89.
Williams AV, Strang J, Marsden J. Development of Opioid Overdose Knowledge (OOKS) and Attitudes (OOAS) Scales for take-home naloxone training evaluation. Drug Alcohol Depend. 2013;132:383-386.
Ehrhart MG, Aarons GA, Farahnak LR. Assessing the organizational context for EBP implementation: The development and validity testing of the Implementation Climate Scale (ICS). Implement Sci. 2014;9:157.
Tabachnick BG, Fidell LS. Using multivariate statistics, 6th edn Boston. MA: Pearson; 2013.
Zimmerman DW. Teacher's corner: A note on interpretation of the paired-samples t test. J Educ Behav Stat. 1997;22:349-360.
Cohen J. Statistical power analysis for the behavioral sciences: Academic press; 2013
Satorra A, Bentler PM. A scaled difference chi-square test statistic for moment structure analysis. Psychometrika. 2001;66:507-514.
Cheung GW, Lau RS. Testing mediation and suppression effects of latent variables: Bootstrapping with structural equation models. Organ Res Methods. 2008;11:296-325.
Fan Y, Chen J, Shirkey G, John R, Wu SR, Park H, et al. Applications of structural equation modeling (SEM) in ecological studies: An updated review. Ecol Process. 2016;5:51-112.
Wolf EJ, Harrington KM, Clark SL, Miller MW. Sample Size requirements for structural equation models: An evaluation of power, bias, and solution propriety. Educ Psychol Meas. 2013;76:913-934.
Powell BJ, Fernandez ME, Williams NJ, Aarons GA, Beidas RS, Lewis CC, et al. Enhancing the impact of implementation strategies in healthcare: A research agenda. Front Public Health. 2019;7:3.
Schleider JL, Beidas RS. Harnessing the Single-Session Intervention approach to promote scalable implementation of evidence-based practices in healthcare. Front Health Serv. 2022;2:997406.
Moullin JC, Ely P, Uren H, Staniland L, Nielsen S, Lenton S. Developing a single-session strategy for the implementation of take-home naloxone by community pharmacists using COM-B and design-thinking. Front Health Serv. 2023;3:1227360.
Johnston K, O'Reilly CL, Scholz B, Georgousopoulou EN, Mitchell I. Burnout and the challenges facing pharmacists during COVID-19: results of a national survey. Int J Clin Pharm. 2021;43:716-725.
Parajuli DR, Khanal S, Wechkunanukul KH, Ghimire S, Poudel A. Pharmacy practice in emergency response during the COVID-19 pandemic: Lessons from Australia. Res Social Adm Pharm. 2022;18:3453-3462.
Elbeddini A, Wen CX, Tayefehchamani Y, To A. Mental health issues impacting pharmacists during COVID-19. J Pharm Policy Pract. 2020;13:46.
Varisco TJ, Downs CG, Rathburn KR, Fleming ML, Thornton JD. Applying the capability, opportunity, motivation, and behavior model to identify opportunities to increase pharmacist comfort dispensing naloxone in Texas: A structural equation modeling approach. Int J Drug Policy. 2020;83:102827.
Watson H, Maclaren W, Kerr S. Staff attitudes towards working with drug users: development of the Drug Problems Perceptions Questionnaire. Addiction. 2007;102:206-215.
Cohen J. Statistical power analysis for the behavioral sciences. Abingdon-on -Thames, UK: Routledge; 2013.
Christison GW, Haviland MG, Riggs ML. The medical condition regard scale: measuring reactions to diagnoses. Acad Med. 2002;77:257-262.
Keyworth C, Epton T, Goldthorpe J, Calam R, Armitage CJ. Acceptability, reliability, and validity of a brief measure of capabilities, opportunities, and motivations (“COM-B”). Br J Health Psychol. 2020;25:474-501.
Baumann AA, Hooley C, Kryzer E, Morshed AB, Gutner CA, Malone S, et al. A scoping review of frameworks in empirical studies and a review of dissemination frameworks. Implement Sci. 2022;17:53.

Auteurs

Joanna C Moullin (JC)

School of Population Health, Faculty of Health Sciences, Curtin University, Perth, Australia.
enAble Institute, Curtin University, Perth, Australia.

Lexy Staniland (L)

enAble Institute, Curtin University, Perth, Australia.

Hannah Uren (H)

School of Population Health, Faculty of Health Sciences, Curtin University, Perth, Australia.

Suzanne Nielsen (S)

Monash Addiction Research Centre, Monash University, Melbourne, Australia.

Simon Lenton (S)

enAble Institute, Curtin University, Perth, Australia.
National Drug Research Institute, Curtin University, Perth, Australia.

Classifications MeSH