Comparison of different estimated glomerular filtration rates for monitoring of kidney function in oncology patients.
cystatin C
glomerular filtration rate estimation
kidney function
renal cell carcinoma
tyrosine kinase inhibitors
Journal
Clinical kidney journal
ISSN: 2048-8505
Titre abrégé: Clin Kidney J
Pays: England
ID NLM: 101579321
Informations de publication
Date de publication:
Jan 2024
Jan 2024
Historique:
received:
17
10
2023
medline:
30
1
2024
pubmed:
30
1
2024
entrez:
30
1
2024
Statut:
epublish
Résumé
Tyrosine kinase inhibitors (TKIs) are associated with kidney function deterioration. A shift is ongoing towards glomerular filtration rate (GFR) equations based on other protein markers, such as cystatin C (CSTC) and β-trace protein (BTP). We evaluated various GFR equations for monitoring of kidney function in actively treated oncology patients. We monitored 110 patients receiving a TKI. Blood and urine were collected during therapy. Serum analysis included creatinine (Cr), CSTC and BTP; for consequent GFR determination. Urine was analysed for protein, albumin, immunoglobulin G, and α-1-microglobulin. A similar analysis was done in a patient subgroup receiving immune checkpoint inhibitors (ICI) as prior or subsequent line of therapy. Cr remained constant during TKI treatment ( GFR equations, in which CSTC is incorporated, fail to correctly estimate the GFR in oncology patients treated with TKIs. As TKI-treated patients show clear signs of glomerular injury, further assessment is needed on how to correctly monitor the kidney function in actively treated oncology patients.
Sections du résumé
Background
UNASSIGNED
Tyrosine kinase inhibitors (TKIs) are associated with kidney function deterioration. A shift is ongoing towards glomerular filtration rate (GFR) equations based on other protein markers, such as cystatin C (CSTC) and β-trace protein (BTP). We evaluated various GFR equations for monitoring of kidney function in actively treated oncology patients.
Methods
UNASSIGNED
We monitored 110 patients receiving a TKI. Blood and urine were collected during therapy. Serum analysis included creatinine (Cr), CSTC and BTP; for consequent GFR determination. Urine was analysed for protein, albumin, immunoglobulin G, and α-1-microglobulin. A similar analysis was done in a patient subgroup receiving immune checkpoint inhibitors (ICI) as prior or subsequent line of therapy.
Results
UNASSIGNED
Cr remained constant during TKI treatment (
Conclusion
UNASSIGNED
GFR equations, in which CSTC is incorporated, fail to correctly estimate the GFR in oncology patients treated with TKIs. As TKI-treated patients show clear signs of glomerular injury, further assessment is needed on how to correctly monitor the kidney function in actively treated oncology patients.
Identifiants
pubmed: 38288036
doi: 10.1093/ckj/sfae006
pii: sfae006
pmc: PMC10823486
doi:
Types de publication
Journal Article
Langues
eng
Pagination
sfae006Informations de copyright
© The Author(s) 2024. Published by Oxford University Press on behalf of the ERA.
Déclaration de conflit d'intérêts
T.V. has received support for attending meetings and/or travel from MSD Belgium within the past 36 months. N.L. has received Grants from Bayer, Ipsen, and Janssen within the past 36 months.