Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress.

Journal

Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400

Informations de publication

Date de publication:
30 Jan 2024
Historique:
medline: 30 1 2024
pubmed: 30 1 2024
entrez: 30 1 2024
Statut: ppublish

Résumé

Targeted degradation regulates the activity of the transcriptional repressor Bcl6 and its ability to suppress oxidative stress and inflammation. Here, we report that abundance of endothelial Bcl6 is determined by its interaction with Golgi-localized pannexin 3 (Panx3) and that Bcl6 transcriptional activity protects against vascular oxidative stress. Consistent with data from obese, hypertensive humans, mice with an endothelial cell-specific deficiency in

Identifiants

DOI: 10.1126/scisignal.adg2622 PMID: 38289985
pubmed: 38289985
doi: 10.1126/scisignal.adg2622
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadg2622

Auteurs

Abigail G Wolpe (AG)

Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
ORCID: 0000-0002-4169-3697

Melissa A Luse (MA)

Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
ORCID: 0000-0001-5425-4717

Christopher Baryiames (C)

Department of Chemistry, University of Virginia, Charlottesville, VA 22904, USA.
ORCID: 0000-0001-5683-8126

Wyatt J Schug (WJ)

Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.

Jacob B Wolpe (JB)

Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

Scott R Johnstone (SR)

Fralin Biomedical Research Institute at Virginia Tech Carilion School of Medicine, Center for Vascular and Heart Research, Roanoke, VA 24016, USA.
Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24060, USA.
ORCID: 0000-0003-1920-5033

Luke S Dunaway (LS)

Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
ORCID: 0000-0002-7458-9669

Zuzanna J Juśkiewicz (ZJ)

Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
ORCID: 0009-0006-2612-2665

Skylar A Loeb (SA)

Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
ORCID: 0000-0003-0213-5163

Henry R Askew Page (HR)

Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
ORCID: 0000-0001-8521-6828

Yen-Lin Chen (YL)

Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
ORCID: 0000-0003-1149-394X

Vikram Sabapathy (V)

Center for Immunity, Inflammation, and Regenerative Medicine (CIIR), University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
ORCID: 0000-0002-7319-0998

Caitlin M Pavelec (CM)

Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

Brent Wakefield (B)

Department of Anatomy and Cell Biology, University of Western Ontario, London, ON N6A 5C1, Canada.
ORCID: 0000-0003-4760-9967

Eugenia Cifuentes-Pagano (E)

Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
ORCID: 0000-0002-2482-080X

Mykhaylo V Artamonov (MV)

Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
ORCID: 0000-0002-0848-2054

Avril V Somlyo (AV)

Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
ORCID: 0000-0002-9997-4897

Adam C Straub (AC)

Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Rahul Sharma (R)

Center for Immunity, Inflammation, and Regenerative Medicine (CIIR), University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
ORCID: 0000-0002-3115-3523

Frank Beier (F)

Department of Physiology and Pharmacology, University of Western Ontario, London, ON N6A 5C1, Canada.
ORCID: 0000-0002-8505-7537

Eugene J Barrett (EJ)

Department of Medicine, Division of Endocrinology and Metabolism, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.

Norbert Leitinger (N)

Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
ORCID: 0000-0001-6224-5175

Patrick J Pagano (PJ)

Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
ORCID: 0000-0002-7475-808X

Swapnil K Sonkusare (SK)

Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
ORCID: 0000-0001-9587-9342

Stefanie Redemann (S)

Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
Center for Membrane and Cell Physiology, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
ORCID: 0000-0003-2334-7309

Linda Columbus (L)

Department of Chemistry, University of Virginia, Charlottesville, VA 22904, USA.
ORCID: 0000-0002-2574-0561

Silvia Penuela (S)

Department of Anatomy and Cell Biology, University of Western Ontario, London, ON N6A 5C1, Canada.
Department of Oncology (Division of Experimental Oncology), Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5W9, Canada.
ORCID: 0000-0003-4829-5517

Brant E Isakson (BE)

Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
ORCID: 0000-0002-7692-6294

Classifications MeSH