Early excitatory-inhibitory cortical modifications following skill learning are associated with motor memory consolidation and plasticity overnight.

Journal

Nature communications

ISSN: 2041-1723

Titre abrégé: Nat Commun

Pays: England

ID NLM: 101528555

Informations de publication

Date de publication:
30 Jan 2024

Historique:

received: 19 04 2023

accepted: 08 01 2024

medline: 31 1 2024

pubmed: 31 1 2024

entrez: 30 1 2024

Statut: epublish

Résumé

Consolidation of motor memories is vital to offline enhancement of new motor skills and involves short and longer-term offline processes following learning. While emerging evidence link glutamate and GABA dynamics in the primary motor cortex (M1) to online motor skill practice, its relationship with offline consolidation processes in humans is unclear. Using two-day repeated measures of behavioral and multimodal neuroimaging data before and following motor sequence learning, we show that short-term glutamatergic and GABAergic responses in M1 within minutes after learning were associated with longer-term learning-induced functional, structural, and behavioral modifications overnight. Furthermore, Glutamatergic and GABAergic modifications were differentially associated with different facets of motor memory consolidation. Our results point to unique and distinct roles of Glutamate and GABA in motor memory consolidation processes in the human brain across timescales and mechanistic levels, tying short-term changes on the neurochemical level to overnight changes in macroscale structure, function, and behavior.

Identifiants

DOI: 10.1038/s41467-024-44979-9 PMID: 38291029

pubmed: 38291029

doi: 10.1038/s41467-024-44979-9

pii: 10.1038/s41467-024-44979-9

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

906

Subventions

Organisme : Israel Science Foundation (ISF)

ID : 416/20

Informations de copyright

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