B12 deficiency-related glossitis is highly associated with high gastrin-17 and low pepsinogen I.

gastrin-17 glossitis pepsinogen I vitamin B12 deficiency

Journal

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
ISSN: 1600-0714
Titre abrégé: J Oral Pathol Med
Pays: Denmark
ID NLM: 8911934

Informations de publication

Date de publication:
30 Jan 2024
Historique:
revised: 31 10 2023
received: 13 10 2023
accepted: 18 01 2024
medline: 31 1 2024
pubmed: 31 1 2024
entrez: 30 1 2024
Statut: aheadofprint

Résumé

The causes of vitamin B12 (B12) deficiency are varied and mainly related to gastric disorders. Glossitis is a common oral manifestation of B12 deficiency and is often first seen by dentists. This study aimed to investigate the correlation between B12 deficiency-related glossitis (B12-def glossitis) and gastric serum biomarkers [gastrin-17(G17), pepsinogen I (PGI), pepsinogen II (PGII), and anti-Helicobacter pylori (H. pylori) antibodies], and preliminarily discuss the etiology of B12-def glossitis. A cross-sectional study was conducted in patients complaining of glossodynia, burning sensation, or severe recurrent oral ulcers, but patients with a history of gastrectomy were excluded. All subjects underwent a uniform oral examination and hematological tests. Of 243 patients, 133 with B12-def glossitis were in the case group, and 110 with other oral mucosal diseases (non-glossitis) and normal B12 levels were in the control group. In the case group, 84.2% (112/133) showed high G17 and low PGI levels (G17 Gastric serum biomarkers in patients with B12-def glossitis generally showed G17

Sections du résumé

BACKGROUND BACKGROUND
The causes of vitamin B12 (B12) deficiency are varied and mainly related to gastric disorders. Glossitis is a common oral manifestation of B12 deficiency and is often first seen by dentists. This study aimed to investigate the correlation between B12 deficiency-related glossitis (B12-def glossitis) and gastric serum biomarkers [gastrin-17(G17), pepsinogen I (PGI), pepsinogen II (PGII), and anti-Helicobacter pylori (H. pylori) antibodies], and preliminarily discuss the etiology of B12-def glossitis.
METHODS METHODS
A cross-sectional study was conducted in patients complaining of glossodynia, burning sensation, or severe recurrent oral ulcers, but patients with a history of gastrectomy were excluded. All subjects underwent a uniform oral examination and hematological tests.
RESULTS RESULTS
Of 243 patients, 133 with B12-def glossitis were in the case group, and 110 with other oral mucosal diseases (non-glossitis) and normal B12 levels were in the control group. In the case group, 84.2% (112/133) showed high G17 and low PGI levels (G17
CONCLUSION CONCLUSIONS
Gastric serum biomarkers in patients with B12-def glossitis generally showed G17

Identifiants

DOI: 10.1111/jop.13511 PMID: 38291532
pubmed: 38291532
doi: 10.1111/jop.13511
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Clinical Research Funding, Shanghai Municipal Health Commission. Grant No.202040458

Informations de copyright

© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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Auteurs

Jingci Zhu (J)

Department of Stomatology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
ORCID: 0009-0005-9416-2354

Yining He (Y)

Biostatistics Office of Clinical Research Unit, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Huang Feng (H)

Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Yufeng Wang (Y)

Department of Oral Medicine, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
National Clinical Research Center for Oral Diseases, Shanghai, China.
Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Shanghai, China.

Zili Ge (Z)

Department of Stomatology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Classifications MeSH