Impact of spatial clustering of cytotoxic and tumor infiltrating lymphocytes on overall survival in women with high grade serous ovarian cancer.

Background

Studies have shown that tumor infiltrating lymphocyte (TILs) abundance is associated with overall survival in patients with high-grade serous ovarian cancer (HGSOC); however, the role of the spatial contexture and organization of TILs is less clear.

Methods

We evaluated the association between spatial architecture of T cells and survival in women with HGSOC from three large epidemiological studies in which tumors were analyzed by multiplex immunofluorescence (N = 433). A Ripley's

Results

We found having high abundance and low spatial clustering of CD3

Conclusion

High abundance of TILs and CTLs that are spatially distributed across the tumor was associated with better survival, replicating our work in non-Hispanic Black women, and supporting that the spatial architecture of the tumor microenvironment is an important predictor of survival in HGSOC.