Analytical Challenges in Omics Research on Asthma and Allergy: A National Institute of Allergy and Infectious Diseases Workshop.

allergic diseases allergy asthma causal inference epigenomics genomics integrative lipidomics microbiome omics proteomics: metabolomics systems biology transcriptomics

Journal

The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002

Informations de publication

Date de publication:
29 Jan 2024
Historique:
received: 13 12 2023
revised: 19 01 2024
accepted: 24 01 2024
medline: 1 2 2024
pubmed: 1 2 2024
entrez: 31 1 2024
Statut: aheadofprint

Résumé

Studies of asthma and allergy are generating increasing volumes of omics data for analysis and interpretation. The National Institute of Allergy and Infectious Diseases (NIAID) assembled a workshop comprised of investigators studying asthma and allergic diseases using omics approaches, omics investigators from outside the field, and NIAID medical and scientific officers to discuss the following areas in asthma and allergy research: genomics, epigenomics, transcriptomics, microbiomics, metabolomics, proteomics, lipidomics, integrative omics, systems biology, and causal inference. Current states-of-the art, present challenges, novel and emerging strategies, and priorities for progress were presented and discussed for each area. This workshop report summarizes the major points and conclusions from this NIAID workshop. As a group, the investigators underscored the imperatives for rigorous analytic frameworks, integration of different omics data types, cross-disciplinary interaction, strategies for overcoming current limitations, and the overarching goal to improve scientific understanding and care of asthma and allergic diseases.

Identifiants

DOI: 10.1016/j.jaci.2024.01.014 PMID: 38295882
pubmed: 38295882
pii: S0091-6749(24)00082-4
doi: 10.1016/j.jaci.2024.01.014
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Auteurs

Supinda Bunyavanich (S)

Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: supinda@post.harvard.edu.

Patrice M Becker (PM)

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Matthew C Altman (MC)

University of Washington, Seattle, WA, USA.

Jessica Lasky-Su (J)

Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.

Carole Ober (C)

University of Chicago, Chicago, IL, USA.

Karsten Zengler (K)

University of California, San Diego, CA, USA.

Evgeny Berdyshev (E)

National Jewish Health, Denver, CO, USA.

Richard Bonneau (R)

Genentech, New York, NY, USA.

Talal Chatila (T)

Boston Children's Hospital and Harvard Medical School, Boston, USA.

Nilanjan Chatterjee (N)

Johns Hopkins University, Baltimore, MD, USA.

Kian Fan Chung (KF)

Imperial College, London, UK.

Colleen Cutcliffe (C)

Pendulum Therapeutics, San Francisco, CA, USA.

Wendy Davidson (W)

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Gang Dong (G)

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Gang Fang (G)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Patricia Fulkerson (P)

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Blanca E Himes (BE)

University of Pennsylvania, Philadelphia, PA USA.

Liming Liang (L)

Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Rasika A Mathias (RA)

Johns Hopkins University, Baltimore, MD, USA.

Shuji Ogino (S)

Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA; Harvard T.H. Chan School of Public Health, Boston, MA, USA; Broad Institute of MIT and Harvard, Boston, MA, USA.

Joseph Petrosino (J)

Baylor College of Medicine, Houston, TX, USA.

Nathan D Price (ND)

Thorne HealthTech, New York, NY, USA.

Eric Schadt (E)

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

James Schofield (J)

University of Southampton, Southampton, UK.

Max A Seibold (MA)

National Jewish Health, Denver, CO, USA; University of Colorado School of Medicine, Aurora, CO, USA.

Hanno Steen (H)

Boston Children's Hospital and Harvard Medical School, Boston, USA.

Lisa Wheatley (L)

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Hongmei Zhang (H)

School of Public Health, University of Memphis, Memphis, TN, USA.

Alkis Togias (A)

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Kohei Hasegawa (K)

Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Classifications MeSH