[Metabolic Activities Catalyzed by Human Cytochrome P450 (CYP) 2D6 and CYP3A Subfamily Members and Effect of Various Compounds, Including Endogenous Steroid Hormones, on These Activities].
cytochrome P450 2D6
cytochrome P450 3A subfamily member
dopamine formation
polymorphism
psychotropic agent
steroid hormone hydroxylation
Journal
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
ISSN: 1347-5231
Titre abrégé: Yakugaku Zasshi
Pays: Japan
ID NLM: 0413613
Informations de publication
Date de publication:
2024
2024
Historique:
medline:
6
2
2024
pubmed:
1
2
2024
entrez:
31
1
2024
Statut:
ppublish
Résumé
My research focused on the effects of various drugs on (1) dopamine formation from p-tyramine catalyzed by polymorphic cytochrome P450 (CYP or P450) 2D6 variants and (2) endogenous steroid hormone hydroxylation catalyzed by CYP3A subfamily members (CYP3A4, CYP3A5, CYP3A7). The activation (cooperativity) of metabolic reactions catalyzed by P450s was especially emphasized. The effects of various psychotropic agents on dopamine formation from p-tyramine, catalyzed by wild-type CYP2D6.1 and CYP2D6 variants, including CYP2D6.2 (Arg296Cys;Ser486Thr), CYP2D6.10 (Pro34Ser;Ser486Thr), and CYP2D6.39 (Ser486Thr) were compared. Michaelis (K
Identifiants
pubmed: 38296497
doi: 10.1248/yakushi.23-00174
doi:
Types de publication
English Abstract
Journal Article
Langues
jpn
Sous-ensembles de citation
IM