Atypical Wernicke's encephalopathy without mental status changes following bariatric surgery in an adolescent patient.

Neuroimaging Nutritional support Obesity (nutrition) Paediatrics (drugs and medicines) Vitamins and supplements

Journal

BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291

Informations de publication

Date de publication:
31 Jan 2024
Historique:
pmc-release: 31 01 2026
medline: 1 2 2024
pubmed: 1 2 2024
entrez: 31 1 2024
Statut: epublish

Résumé

Morbid obesity is a systemic disease which can result in chronic complications, including hypertension, diabetes mellitus, depression, osteoarthritis and low self-esteem in the adolescent population.Bariatric surgery can be indicated to treat more severe forms of obesity, but these procedures are not without long-term risks. Therefore, adequate preoperative and postoperative care, which includes preoperative psychosocial evaluation for compliance, ongoing nutrition counselling and vitamin and micronutrient supplementation, is required for all patients, especially adolescent patients, who generally may not comply with medical therapies and/or be able to developmentally fully appreciate or comprehend the health consequences of their behaviours, prior to as well as after bariatric surgery to prevent complications.Thiamine pyrophosphate, an active form of thiamine (also known as vitamin B1, a water-soluble vitamin), which functions as a coenzyme in glucose and energy metabolism, is one such vitamin that requires supplementation postoperatively. It is mandatory for glucose to be administered concomitantly with thiamine, as glucose alone can precipitate Wernicke's encephalopathy (WE) in thiamine-deficient individuals. WE is a medical emergency, with a mortality rate of up to 20%. WE is best understood as a classic triad of mental confusion, gait ataxia and eye movement abnormalities, and atypical WE or Wernicke's syndrome (WS) is seen when the classic triad is not present. Cases that meet some, but do not necessarily meet all three criteria, are referred to as atypical WE or WS which can lead to delayed diagnosis. Atypical WE has an incidence of 19% which can lead to misdiagnosis of a preventable medical emergency with fatal complications.The following case reviews the consequences of post-bariatric thiamine supplementation therapy non-adherence and resulting in a deficiency in an adolescent patient.

Identifiants

pubmed: 38296505
pii: 17/1/e255507
doi: 10.1136/bcr-2023-255507
pmc: PMC10831428
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

Auteurs

Asra Akbar (A)

Pediatric Neurology, University of Illinois college of medicine in peoria, Peoria, Illinois, USA aakbar1@uic.edu.

Jason Lowther (J)

University of Illinois College of Medicine at Chicago, Chicago, Illinois, USA.

Sean Creeden (S)

University of Illinois Chicago College of Medicine at Peoria, Peoria, Illinois, USA.

William Frese (W)

University of Illinois Chicago College of Medicine at Peoria, Peoria, Illinois, USA.

Classifications MeSH