Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
31 Jan 2024
31 Jan 2024
Historique:
received:
15
06
2023
accepted:
15
11
2023
medline:
1
2
2024
pubmed:
1
2
2024
entrez:
31
1
2024
Statut:
epublish
Résumé
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome.
Identifiants
pubmed: 38296965
doi: 10.1038/s41467-023-43644-x
pii: 10.1038/s41467-023-43644-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
924Subventions
Organisme : DH | National Institute for Health Research (NIHR)
ID : MC_PC_19056
Organisme : RCUK | Medical Research Council (MRC)
ID : MC_PC_19056
Investigateurs
Peter Sandercock
(P)
Janet Darbyshire
(J)
David DeMets
(D)
Robert Fowler
(R)
David Lalloo
(D)
Mohammed Munavvar
(M)
Adilia Warris
(A)
Janet Wittes
(J)
A Cradduck-Bamford
(A)
J Barton
(J)
A Basoglu
(A)
R Brown
(R)
W Brudlo
(W)
E Denis
(E)
L Fletcher
(L)
S Howard
(S)
K Taylor
(K)
G Cui
(G)
B Goodenough
(B)
A King
(A)
M Lay
(M)
D Murray
(D)
W Stevens
(W)
K Wallendszus
(K)
R Wels
(R)
C Crichton
(C)
J Davies
(J)
R Goldacre
(R)
C Harper
(C)
F Knight
(F)
M Nunn
(M)
H Salih
(H)
J Welch
(J)
M Zayed
(M)
J Wiles
(J)
G Bagley
(G)
S Cameron
(S)
S Chamberlain
(S)
B Farrell
(B)
H Freeman
(H)
A Kennedy
(A)
A Whitehouse
(A)
S Wilkinson
(S)
C Wood
(C)
C Reith
(C)
K Davies
(K)
H Halls
(H)
L Holland
(L)
R Truell
(R)
K Wilson
(K)
L Howie
(L)
M Lunn
(M)
P Rodgers
(P)
L Bowman
(L)
F Chen
(F)
R Clarke
(R)
M Goonasekara
(M)
W Herrington
(W)
P Judge
(P)
S Ng
(S)
D Preiss
(D)
E Sammons
(E)
D Zhu
(D)
A Barnard
(A)
J Beety
(J)
C Birch
(C)
M Brend
(M)
E Chambers
(E)
L Chappell
(L)
S Crawshaw
(S)
C Drake
(C)
H Duckles-Leech
(H)
J Graham
(J)
T Harman
(T)
H Harper
(H)
S Lock
(S)
K Lomme
(K)
N McMillan
(N)
I Nickson
(I)
U Ohia
(U)
E OKell
(E)
V Poustie
(V)
S Sam
(S)
P Sharratt
(P)
J Sheffield
(J)
H Slade
(H)
W Van't Hoff
(W)
S Walker
(S)
J Williamson
(J)
A De Soyza
(A)
P Dimitri
(P)
S N Faust
(SN)
N Lemoine
(N)
J Minton
(J)
K Gilmour
(K)
K Pearson
(K)
C Armah
(C)
D Campbell
(D)
H Cate
(H)
A Priest
(A)
E Thomas
(E)
R Usher
(R)
G Johnson
(G)
M Logan
(M)
S Pratt
(S)
A Price
(A)
K Shirley
(K)
E Walton
(E)
P Williams
(P)
F Yelnoorkar
(F)
J Hanson
(J)
H Membrey
(H)
L Gill
(L)
A Oliver
(A)
S Das
(S)
S Murphy
(S)
M Sutu
(M)
J Collins
(J)
H Monaghan
(H)
A Unsworth
(A)
S Beddows
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K Barker-Williams
(K)
S Dowling
(S)
K Gibbons
(K)
K Pine
(K)
A Asghar
(A)
P Aubrey
(P)
D Beaumont-Jewell
(D)
K Donaldson
(K)
T Skinner
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J Luo
(J)
N Mguni
(N)
N Muzengi
(N)
R Pleass
(R)
E Wayman
(E)
A Coe
(A)
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(J)
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(C)
A Potter
(A)
J Taylor
(J)
M Dolman
(M)
L Gerdes
(L)
C Hall
(C)
T Lockett
(T)
D Porter
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J Bartholomew
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L Dowden
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C Rook
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E Denton
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H Tinkler
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P Boyle
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M Brookes
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C Callens
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H Duffy
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C Green
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K Hampshire
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S Harrison
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J Kirk
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M Naz
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P Ryan
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J Shenton
(J)
J Warmington
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M Amezaga
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J Goodwin
(J)
H Hodgson
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M Odam
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D Williamson
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H Pinches
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P Bowker
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V Byrne-Watts
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G Chapman
(G)
G Coleman
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J Gray
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A Rees
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N Mather
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T Denwood
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D Harrison
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J Bruce
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A Chakraborty
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R Srinivasan
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K Stewart
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G Wallace
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Informations de copyright
© 2024. The Author(s).
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